SPOCK1 and MMP2

Number of citations of the paper that reports this interaction (PMID 12810672)
12

Data Source:
HPRD (in vitro)

		SPOCK1	MMP2
Gene Name		sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Postsynaptic Density Sarcoplasm Neuromuscular Junction Node Of Ranvier	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Metalloendopeptidase Inhibitor Activity	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Cell Growth Neuron Migration Cell Adhesion Signal Transduction Nervous System Development Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Negative Regulation Of Neuron Projection Development Central Nervous System Neuron Differentiation Neurogenesis	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Axon Guidance Embryo Implantation Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Cellular Protein Metabolic Process Positive Regulation Of Innate Immune Response Ephrin Receptor Signaling Pathway Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus
Pathways			Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Axon guidance Collagen degradation Activation of Matrix Metalloproteinases EPH-Ephrin signaling Degradation of the extracellular matrix
Drugs			Marimastat Captopril SC-74020
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MMP14 MMP2 MMP3	34 interactors: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		6695	4313
HPRD ID		11887	00386
Ensembl ID		ENSG00000152377	ENSG00000087245
Uniprot IDs		D3DQB3 Q08629	P08253
PDB IDs			1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Cellular Response To Amino Acid Stimulus Endoderm Development Response To Amino Acid Formation Of Primary Germ Layer Cellular Response To Acid Chemical Gastrulation Proteolysis Skeletal System Morphogenesis Ossification Catabolic Process Response To Hypoxia Negative Regulation Of Hydrogen Peroxide Metabolic Process Angiogenesis Positive Regulation Of Oxidative Stress-induced Cell Death Astrocyte Cell Migration Response To Oxidative Stress Blood Vessel Morphogenesis Intramembranous Ossification Chondrocyte Proliferation Cellular Response To Organonitrogen Compound Regulation Of Hydrogen Peroxide Metabolic Process Bone Trabecula Formation Response To Organic Substance Blood Vessel Development Vasculature Development Blood Vessel Maturation Cellular Response To Nitric Oxide Skeletal System Development Regulation Of Cell Migration Response To Nitric Oxide Craniofacial Suture Morphogenesis Regulation Of Cell Motility Bone Trabecula Morphogenesis Endothelial Cell Proliferation Embryonic Morphogenesis Positive Regulation Of Protein Oligomerization Regulation Of Locomotion Negative Regulation Of Focal Adhesion Assembly Regulation Of Cellular Component Movement Cellular Response To Reactive Nitrogen Species Response To Stress	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Peptidase Activity Regulation Of Cell Migration Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Motility Negative Regulation Of Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Protein Processing Regulation Of Proteolysis Developmental Process Regulation Of Locomotion Regulation Of Endopeptidase Activity Regulation Of Cellular Component Movement Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Cell Adhesion Locomotion Positive Regulation Of Cell Migration Response To External Stimulus Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Anatomical Structure Development Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Cell Migration Negative Regulation Of Cell Adhesion Multicellular Organismal Development Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Cell Motility Collagen Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Locomotion Skeletal System Development System Development Collagen Metabolic Process Chemotaxis Cell Differentiation Multicellular Organismal Macromolecule Metabolic Process Regulation Of Cell Adhesion Multicellular Organismal Metabolic Process
Tagcloud ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 casp5 chromosomes clustered dad1 gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp vmat1	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Difference) ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 casp5 chromosomes clustered dad1 gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp vmat1	5microm actin anxa2 beside depend depends evoked fibroblasts fro h2o2 likewise metalloproteinase mitogenic mmps nsmase2 p38mapk peroxide pretreated remodeling reorganization ro28 sb203580 shape smc sphingolipid sphingomyelinase src triggered unable
Tagcloud (Intersection) ?