SPOCK1 and MMP14

Number of citations of the paper that reports this interaction (PMID 12810672)
12

Data Source:
HPRD (in vitro)

		SPOCK1	MMP14
Gene Name		sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	matrix metallopeptidase 14 (membrane-inserted)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Postsynaptic Density Sarcoplasm Neuromuscular Junction Node Of Ranvier	Cytoplasm Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Melanosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Metalloendopeptidase Inhibitor Activity	Sequence-specific DNA Binding Transcription Factor Activity Metalloendopeptidase Activity Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Peptidase Activator Activity
	Biological Process	Regulation Of Cell Growth Neuron Migration Cell Adhesion Signal Transduction Nervous System Development Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Negative Regulation Of Neuron Projection Development Central Nervous System Neuron Differentiation Neurogenesis	Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Regulation Of Transcription, DNA-templated Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Positive Regulation Of Peptidase Activity Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Negative Regulation Of Focal Adhesion Assembly Craniofacial Suture Morphogenesis
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: MMP14 MMP2 MMP3	23 interactors: ACAN ADI1 BCAR1 C1QBP CAV1 CCDC155 CCL7 CLDN1 F12 ITGAV KISS1 LRP1 LUM MMP13 MMP2 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP2 TIMP3 TIMP4
Entrez ID		6695	4323
HPRD ID		11887	02856
Ensembl ID		ENSG00000152377	ENSG00000157227
Uniprot IDs		D3DQB3 Q08629	P50281
PDB IDs			1BQQ 1BUV 3C7X 3MA2
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endodermal Cell Differentiation Endoderm Formation Cellular Response To Amino Acid Stimulus Endoderm Development Response To Amino Acid Formation Of Primary Germ Layer Cellular Response To Acid Chemical Gastrulation Proteolysis Skeletal System Morphogenesis Ossification Catabolic Process Response To Hypoxia Negative Regulation Of Hydrogen Peroxide Metabolic Process Angiogenesis Positive Regulation Of Oxidative Stress-induced Cell Death Astrocyte Cell Migration Response To Oxidative Stress Blood Vessel Morphogenesis Intramembranous Ossification Chondrocyte Proliferation Cellular Response To Organonitrogen Compound Regulation Of Hydrogen Peroxide Metabolic Process Bone Trabecula Formation Response To Organic Substance Blood Vessel Development Vasculature Development Blood Vessel Maturation Cellular Response To Nitric Oxide Skeletal System Development Regulation Of Cell Migration Response To Nitric Oxide Craniofacial Suture Morphogenesis Regulation Of Cell Motility Bone Trabecula Morphogenesis Endothelial Cell Proliferation Embryonic Morphogenesis Positive Regulation Of Protein Oligomerization Regulation Of Locomotion Negative Regulation Of Focal Adhesion Assembly Regulation Of Cellular Component Movement Cellular Response To Reactive Nitrogen Species Response To Stress	Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Protein Processing Regulation Of Peptidase Activity Extracellular Matrix Disassembly Response To Wounding Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Protein Metabolic Process Regulation Of Body Fluid Levels Sulfur Compound Metabolic Process Wound Healing Negative Regulation Of Proteolysis Response To Stimulus Glycosaminoglycan Catabolic Process Glycosaminoglycan Metabolic Process Negative Regulation Of Protein Processing System Development Anatomical Structure Development Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Hydrolase Activity Regulation Of Cellular Component Movement Blood Coagulation Hemostasis Keratan Sulfate Catabolic Process Response To Organic Substance Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Developmental Process Regulation Of Protein Metabolic Process Multicellular Organismal Development Blood Coagulation, Intrinsic Pathway Glycosaminoglycan Biosynthetic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Proteoglycan Metabolic Process Response To External Stimulus Negative Regulation Of Protein Catabolic Process Regulation Of Cell Migration Response To Hormone Positive Regulation Of Cell Migration Keratan Sulfate Biosynthetic Process Positive Regulation Of Cell Motility Regulation Of Cell Motility Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Keratan Sulfate Metabolic Process
Tagcloud ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 casp5 chromosomes clustered dad1 gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp vmat1	5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Difference) ?		11q 18q21 18q22 3p aplp1 carcinoids casp1 casp4 casp5 chromosomes clustered dad1 gains gpr112 hierarchical il12a ileal mir133a or51e1 paid prkca profiling q21 q22 q23 ret runx1 rybp vmat1	5p analyze diagnostics differentially focused functionally hcc hepatocarcinogenesis hepatocellular hepatoma identifying inhibiting invasion metalloproteinase microarray migration mir mirna mirnas pair progress promotes qpcr re reverses suppresses tissues validated worldwide
Tagcloud (Intersection) ?