SPG7 and PNMA1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPG7	PNMA1
Gene Name		spastic paraplegia 7 (pure and complicated autosomal recessive)	paraneoplastic Ma antigen 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane Mitochondrial Membrane	Nucleolus Cytoplasm Focal Adhesion
	Molecular Function	Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding	Protein Binding
	Biological Process	Proteolysis Mitochondrion Organization Nervous System Development Anterograde Axon Cargo Transport	Inflammatory Response To Antigenic Stimulus Positive Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NL PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SPATS1 STAMBP TRIM28	114 interactors: ANKRD36BP1 APTX ARID5A ASMTL ATP5O ATXN7 BEX2 BYSL C14orf105 C21orf58 C5orf30 C8orf33 CARHSP1 CCDC146 CCDC33 CCNG1 CCP110 CDK18 CFAP53 CHIC2 CHMP2B CNNM3 COX5B DCTN4 EHHADH ENKD1 FAM107A FAM110A FBF1 FBXL18 FEM1C FMNL2 GEM GPANK1 GPR25 GTPBP10 HDAC4 HOXB9 INO80B KANSL1 KAT2B LENG1 LIN37 MAB21L2 MARK4 MCM7 MED8 METTL17 MRPL10 MRPL11 MRPL23 MSI1 NPBWR2 NUDT16L1 PARD3 PARD6B PIN1 PIN4 PNMA5 PNMA6A POLDIP3 POLL POLM PRKCG PRKCI PRPF31 PSMA1 RAPGEF3 RBM41 RPP25L RSPH9 RSRC2 RTP5 RUSC1 SCAND1 SCNM1 SDCBP SEMA4C SH2D4A SHISA3 SLC25A48 SLIRP SMIM3 SNRPB SNRPB2 SPATC1L SPG7 STAMBPL1 SUV39H2 TCEANC TEAD4 TMSB4X TNNI1 TNNT1 TRIM42 TRPV6 TSPYL4 TTC9C TXNDC9 UBQLN1 UBQLN4 URB1-AS1 USP2 VAV2 VBP1 WDR25 WDYHV1 WT1-AS ZC2HC1C ZCCHC12 ZFYVE26 ZG16B ZNF564 ZNF581
Entrez ID		6687	9240
HPRD ID		04149	04926
Ensembl ID		ENSG00000197912	ENSG00000176903
Uniprot IDs		Q9UQ90	Q8ND90
PDB IDs		2QZ4
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Nucleus Regulation Of Protein Import Into Nucleus Negative Regulation Of Wnt Signaling Pathway Regulation Of Cellular Process Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Viral Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of DNA Demethylation Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Regulation Of Protein Localization Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Cytokinesis Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Embryonic Placenta Development Transcription, DNA-templated Inflammatory Response Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Intracellular Transport RNA Metabolic Process RNA Biosynthetic Process Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting Phosphatidylserine Biosynthetic Process DNA Methylation Involved In Embryo Development Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Viral Process Response To Stimulus Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Intracellular Protein Transport RNA Processing Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Spindle Midzone Assembly Placenta Development Positive Regulation Of Protein Metabolic Process Phospholipid Scrambling Regulation Of Protein Transport	Cell Cycle Apical Junction Assembly Organelle Organization Histone H3-K9 Modification
Tagcloud ?		ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness	adenocarcinoma apoptotic autoimmune bcl besides closely commonly decreases ductal erk expanding find mapk member neurological pancreatic paraneoplastic pdac pi3k pns pro promotes represent reveal suppression testis viability widely
Tagcloud (Difference) ?		ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness	adenocarcinoma apoptotic autoimmune bcl besides closely commonly decreases ductal erk expanding find mapk member neurological pancreatic paraneoplastic pdac pi3k pns pro promotes represent reveal suppression testis viability widely
Tagcloud (Intersection) ?