PNMA1 and PARD3

Number of citations of the paper that reports this interaction (PMID 14676191)
42

Data Source:
HPRD (in vivo)

		PNMA1	PARD3
Gene Name		paraneoplastic Ma antigen 1	par-3 family cell polarity regulator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Focal Adhesion	Spindle Cytosol Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Tight Junction Cell Cortex Endomembrane System Cell Junction Internode Region Of Axon Neuronal Cell Body Protein Complex Axonal Growth Cone Apical Part Of Cell
	Molecular Function	Protein Binding	Protein Kinase C Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Positive Regulation Of Apoptotic Process	Microtubule Cytoskeleton Organization Apical Constriction Protein Complex Assembly Protein Targeting To Membrane Cell Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Axonogenesis Asymmetric Cell Division Negative Regulation Of Peptidyl-threonine Phosphorylation Myelination In Peripheral Nervous System Positive Regulation Of Myelination Regulation Of Actin Filament-based Process Cell Junction Assembly Wound Healing, Spreading Of Cells Cell-cell Junction Organization Centrosome Localization Regulation Of Cellular Localization Tight Junction Assembly Establishment Of Epithelial Cell Polarity
Pathways			Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 19684603) Emphysema-related traits ( 20709820) Major depressive disorder ( 21621269) Schizophrenia ( 21682944)
Protein-Protein Interactions		114 interactors: ANKRD36BP1 APTX ARID5A ASMTL ATP5O ATXN7 BEX2 BYSL C14orf105 C21orf58 C5orf30 C8orf33 CARHSP1 CCDC146 CCDC33 CCNG1 CCP110 CDK18 CFAP53 CHIC2 CHMP2B CNNM3 COX5B DCTN4 EHHADH ENKD1 FAM107A FAM110A FBF1 FBXL18 FEM1C FMNL2 GEM GPANK1 GPR25 GTPBP10 HDAC4 HOXB9 INO80B KANSL1 KAT2B LENG1 LIN37 MAB21L2 MARK4 MCM7 MED8 METTL17 MRPL10 MRPL11 MRPL23 MSI1 NPBWR2 NUDT16L1 PARD3 PARD6B PIN1 PIN4 PNMA5 PNMA6A POLDIP3 POLL POLM PRKCG PRKCI PRPF31 PSMA1 RAPGEF3 RBM41 RPP25L RSPH9 RSRC2 RTP5 RUSC1 SCAND1 SCNM1 SDCBP SEMA4C SH2D4A SHISA3 SLC25A48 SLIRP SMIM3 SNRPB SNRPB2 SPATC1L SPG7 STAMBPL1 SUV39H2 TCEANC TEAD4 TMSB4X TNNI1 TNNT1 TRIM42 TRPV6 TSPYL4 TTC9C TXNDC9 UBQLN1 UBQLN4 URB1-AS1 USP2 VAV2 VBP1 WDR25 WDYHV1 WT1-AS ZC2HC1C ZCCHC12 ZFYVE26 ZG16B ZNF564 ZNF581	27 interactors: CDC42 DYNLL1 F11R INADL INSC LIMK2 PARD6A PARD6B PARD6G PLCB1 PLCB3 PNMA1 PRKCG PRKCI PVRL1 PVRL3 SMAD2 SMAD3 SMAD4 SMAD7 STK11 TIAM1 TIAM2 YWHAB YWHAG YWHAH YWHAZ
Entrez ID		9240	56288
HPRD ID		04926	05994
Ensembl ID		ENSG00000176903	ENSG00000148498
Uniprot IDs		Q8ND90	Q8TEW0
PDB IDs			2KOM
Enriched GO Terms of Interacting Partners?		Cell Cycle Apical Junction Assembly Organelle Organization Histone H3-K9 Modification	Cell-cell Junction Organization Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Cell Junction Assembly Cellular Response To Growth Factor Stimulus Cellular Component Assembly Tight Junction Assembly Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Component Organization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Intracellular Transport Apical Junction Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signal Transduction Cellular Response To Organic Substance Regulation Of Cell Death Positive Regulation Of Transport Cell-cell Junction Assembly Signaling Positive Regulation Of Mitochondrion Organization Cell Communication Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Development Regulation Of Intracellular Transport Regulation Of Apoptotic Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation System Development Regulation Of Establishment Of Protein Localization Nervous System Development Regulation Of Cell Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Anatomical Structure Development Regulation Of Signal Transduction Response To Transforming Growth Factor Beta Positive Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway SMAD Protein Complex Assembly Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cellular Localization Response To Organic Substance Regulation Of Protein Localization Multicellular Organismal Development
Tagcloud ?		adenocarcinoma apoptotic autoimmune bcl besides closely commonly decreases ductal erk expanding find mapk member neurological pancreatic paraneoplastic pdac pi3k pns pro promotes represent reveal suppression testis viability widely	antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta
Tagcloud (Difference) ?		adenocarcinoma apoptotic autoimmune bcl besides closely commonly decreases ductal erk expanding find mapk member neurological pancreatic paraneoplastic pdac pi3k pns pro promotes represent reveal suppression testis viability widely	antisaccade assayed blink disrupt eeg electrodermal endophenotype endophenotypes exome exonic eye illumina kernel maf mapped movements neutral nonsynonymous pleasant pnpla7 polymorphic psychophysiological rare resting snp snps startle technologies theta
Tagcloud (Intersection) ?