PNMA1 and PSMA1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PNMA1	PSMA1
Gene Name		paraneoplastic Ma antigen 1	proteasome (prosome, macropain) subunit, alpha type, 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Focal Adhesion	Proteasome Complex Nucleus Nucleoplasm Centrosome Cytosol Proteasome Core Complex Polysome Proteasome Core Complex, Alpha-subunit Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	RNA Binding Threonine-type Endopeptidase Activity Protein Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Positive Regulation Of Apoptotic Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		114 interactors: ANKRD36BP1 APTX ARID5A ASMTL ATP5O ATXN7 BEX2 BYSL C14orf105 C21orf58 C5orf30 C8orf33 CARHSP1 CCDC146 CCDC33 CCNG1 CCP110 CDK18 CFAP53 CHIC2 CHMP2B CNNM3 COX5B DCTN4 EHHADH ENKD1 FAM107A FAM110A FBF1 FBXL18 FEM1C FMNL2 GEM GPANK1 GPR25 GTPBP10 HDAC4 HOXB9 INO80B KANSL1 KAT2B LENG1 LIN37 MAB21L2 MARK4 MCM7 MED8 METTL17 MRPL10 MRPL11 MRPL23 MSI1 NPBWR2 NUDT16L1 PARD3 PARD6B PIN1 PIN4 PNMA5 PNMA6A POLDIP3 POLL POLM PRKCG PRKCI PRPF31 PSMA1 RAPGEF3 RBM41 RPP25L RSPH9 RSRC2 RTP5 RUSC1 SCAND1 SCNM1 SDCBP SEMA4C SH2D4A SHISA3 SLC25A48 SLIRP SMIM3 SNRPB SNRPB2 SPATC1L SPG7 STAMBPL1 SUV39H2 TCEANC TEAD4 TMSB4X TNNI1 TNNT1 TRIM42 TRPV6 TSPYL4 TTC9C TXNDC9 UBQLN1 UBQLN4 URB1-AS1 USP2 VAV2 VBP1 WDR25 WDYHV1 WT1-AS ZC2HC1C ZCCHC12 ZFYVE26 ZG16B ZNF564 ZNF581	87 interactors: ABCD3 ABI3 ACTN1 APIP APP BLZF1 C11orf49 CALCOCO2 CBS CCDC102B CCDC85B CCNH CDA CEP70 CEP72 COIL COX2 DLEU1 EHMT2 GLTSCR2 GNPTAB GOLGA2 HOMER3 HSD17B14 IFT20 IKZF1 IKZF3 INO80E KCTD1 KCTD17 KCTD9 KRT15 KRT31 KRT38 KRT40 KRTAP5-9 LDB1 LDOC1 LZTS2 MAD1L1 MAPRE1 MAPRE3 MCM6 MID2 MKRN3 MLH1 MRFAP1L1 MTUS2 NECAB2 NMI NOTCH2NL PARK2 PLK1 PNMA1 PNMA2 PNMA5 POMP PRDM14 PSMA2 PSMA3 PSMA4 PSMA7 PSMB10 PSMB2 PSMB5 PSMB9 RAD54B REL ROPN1 SFMBT1 SH3BP4 SH3GLB1 SSX2IP TCF12 TCF4 TDO2 TNFAIP1 TNR TRAF1 TRIM10 TRIM23 TRIM27 TRIM42 TSC22D4 UBXN11 VCP VIM
Entrez ID		9240	5682
HPRD ID		04926	04170
Ensembl ID		ENSG00000176903	ENSG00000129084
Uniprot IDs		Q8ND90	B4E0X6 P25786
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cycle Apical Junction Assembly Organelle Organization Histone H3-K9 Modification	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Mitotic G1 DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Protein Polyubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Wnt Signaling Pathway Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Negative Regulation Of Protein Ubiquitination
Tagcloud ?		adenocarcinoma apoptotic autoimmune bcl besides closely commonly decreases ductal erk expanding find mapk member neurological pancreatic paraneoplastic pdac pi3k pns pro promotes represent reveal suppression testis viability widely	20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma3 psma5 psma6 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies
Tagcloud (Difference) ?		adenocarcinoma apoptotic autoimmune bcl besides closely commonly decreases ductal erk expanding find mapk member neurological pancreatic paraneoplastic pdac pi3k pns pro promotes represent reveal suppression testis viability widely	20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma3 psma5 psma6 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies
Tagcloud (Intersection) ?