PNMA1 and RAPGEF3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PNMA1	RAPGEF3
Description		PNMA family member 1	Rap guanine nucleotide exchange factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm	Plasma Membrane Microvillus Endomembrane System Membrane Lamellipodium Filopodium Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Domain Specific Binding CAMP Binding
	Biological Process	Inflammatory Response To Antigenic Stimulus Positive Regulation Of Apoptotic Process	Angiogenesis Adaptive Immune Response Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Associative Learning Rap Protein Signal Transduction Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Protein Export From Nucleus Regulation Of Insulin Secretion Positive Regulation Of Stress Fiber Assembly Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Establishment Of Endothelial Barrier Cellular Response To CAMP
Pathways			Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion
Drugs
Diseases
GWAS			A body shape index ( 34021172) Bipolar disorder ( 31043756) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Platelet distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		170 interacting genes: ABHD17A AGTR1 AIRIM ANKRD36BP1 APTX ARHGEF6 ARID5A ASMTL ATP5PO ATP6V1G1 ATXN7 BEX2 BYSL C21orf58 C8orf33 CARHSP1 CBX8 CCDC146 CCDC187 CCDC198 CCDC33 CCNG1 CCP110 CDK18 CFAP53 CFTR CHIC2 CHMP2B CNNM3 COX5B CTNNA3 DAXX DCTN4 EAF2 EHHADH ENKD1 FAM107A FAM110A FAM161A FAM161B FBF1 FBXL18 FEM1C FMNL2 FOXD4L1 FOXD4L3 FXR1 FXR2 GADD45GIP1 GATA1 GEM GPANK1 GPR25 GRAP2 GTPBP10 HAPLN2 HCK HDAC4 HGS HNRNPLL HOXB9 IGFN1 INO80B IVD KANSL1 KAT2B LAGE3 LENG1 LIN37 LMO3 LNX1 LSM2 MAB21L2 MACIR MARK4 MCM7 MED8 METTL17 MRPL10 MRPL11 MRPL23 MSI1 MYO15B MYOZ1 NIF3L1 NPBWR2 NSMF NTAQ1 NUDT16L1 PARD3 PARD6B PCGF6 PER1 PIN1 PIN4 PKN1 PKN3 PNMA5 PNMA6A POLDIP3 POLL POLM PRKAB2 PRKCG PRKCI PRPF18 PRPF31 PSMA1 RAD51D RAPGEF3 RBM41 RPP25 RPP25L RSPH9 RSRC2 RTP5 RUSC1 SCAND1 SCNM1 SDCBP SEMA4C SH2D4A SHC3 SHISA3 SLC25A48 SLIRP SMIM3 SNRPB SNRPB2 SPATC1L SPG7 SSX2IP STAMBPL1 SUV39H2 TASOR2 TCEA2 TCEANC TCL1B TEAD4 TMSB4X TNNI1 TNNT1 TRIM42 TRIM73 TRPV6 TSHZ2 TSPYL4 TTC23 TTC9C TXNDC9 UBQLN1 UBQLN4 URB1-AS1 USP2 VAV2 VBP1 VPS9D1 WDR25 WT1-AS ZC2HC1C ZCCHC12 ZFYVE26 ZG16B ZNF148 ZNF35 ZNF410 ZNF438 ZNF564 ZNF581 ZNF688	14 interacting genes: AP1M1 AP2B1 DAPK1 DDX6 EXOC8 MAP1A OARD1 PNMA1 RAP1A RAP2A RRAS2 TGFB1 UFSP1 ZRANB1
Entrez ID		9240	10411
HPRD ID		04926	06928
Ensembl ID		ENSG00000176903	ENSG00000079337
Uniprot IDs		Q8ND90	O95398 Q99777
PDB IDs			6H7E
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Diacylglycerol-dependent Serine/threonine Kinase Activity PAR Polarity Complex	Clathrin Adaptor Complex GDP Binding Rap Protein Signal Transduction Clathrin Adaptor Activity Response To Hydroperoxide GTP Binding Hydrolase Activity Intracellular Protein Localization Establishment Of Protein Localization Regulation Of Protein Localization To Membrane Regulation Of Response To Tumor Cell DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Concave Side Of Sperm Head Liver Regeneration Regulation Of Collagen Metabolic Process Response To Ketone Regulation Of Collagen Biosynthetic Process Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Branch Elongation Involved In Mammary Gland Duct Branching Positive Regulation Of Microglia Differentiation Cellular Response To Acetaldehyde ADP-ribosyl-[dinitrogen Reductase] Hydrolase Activity Cellular Localization Protein Transport Intracellular Protein Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Viral RNA Genome Packaging Retrograde Axonal Protein Transport Primary Dendrite Response To Antineoplastic Agent Small GTPase-mediated Signal Transduction Animal Organ Regeneration G Protein Activity Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Response To Wortmannin Positive Regulation Of Primary MiRNA Processing Embryonic Liver Development Purine Nucleoside Binding DeUFMylase Activity
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