SPG7 and SPATS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SPG7	SPATS1
Description		SPG7 matrix AAA peptidase subunit, paraplegin	spermatogenesis associated serine rich 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Mitochondrial Permeability Transition Pore Complex Membrane Axon Cytoplasm
	Molecular Function	Nucleotide Binding ATP-dependent Peptidase Activity Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding Unfolded Protein Binding	Protein Binding
	Biological Process	Proteolysis Mitochondrion Organization Nervous System Development Anterograde Axonal Transport Mitochondrial Protein Processing Calcium Import Into The Mitochondrion Regulation Of Mitochondrial Membrane Permeability Regulation Of Calcium Import Into The Mitochondrion Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways		Processing of SMDT1 Mitochondrial protein degradation
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Appendicular lean mass ( 33097823) Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)	Itch intensity from mosquito bite adjusted by bite size ( 28199695)
Interacting Genes		29 interacting genes: BDKRB2 CCNDBP1 CYSRT1 HNRNPK HSF2BP KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NBPF19 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28	9 interacting genes: CFLAR CTNNA3 GPHN KCTD9 MISP SPG7 TRIM55 TRIM63 ZIC1
Entrez ID		6687	221409
HPRD ID		04149	10248
Ensembl ID		ENSG00000197912	ENSG00000249481
Uniprot IDs		A0A2R8Y3M4 A0A2R8Y632 A0A2R8YFJ7 Q9UQ90	Q496A3
PDB IDs		2QZ4
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament	Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Muscle Atrophy Glycine Receptor Clustering Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity M-AAA Complex Microtubule-based Process Skeletal Myofibril Assembly Nitrate Reductase Activity Establishment Of Synaptic Specificity At Neuromuscular Junction Cytoskeleton Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?