SPG7 and CCNDBP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SPG7	CCNDBP1
Gene Name		spastic paraplegia 7 (pure and complicated autosomal recessive)	cyclin D-type binding-protein 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane Mitochondrial Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding	Protein Binding
	Biological Process	Proteolysis Mitochondrion Organization Nervous System Development Anterograde Axon Cargo Transport	Cell Cycle Regulation Of Cell Cycle
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NL PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SPATS1 STAMBP TRIM28	70 interactors: AMPD2 ARHGAP22 ATP4B C22orf23 C6orf226 CCDC108 CCDC146 CCND1 CDK18 CNNM3 CUL5 DMRT3 DOCK2 FAM110A FAM64A FAM74A4 GLIDR GRAP2 GSTK1 ILF2 IMP3 MAP2K2 MOS MRPL15 MRPS9 NAIF1 NANOS2 NEURL3 NUDCD3 PAXIP1 PIAS2 PMP2 PSMB10 PTF1A RBP5 RPL28 RPL39L RPLP0 RPS28 SIRT6 SPG7 STK25 SYF2 TEAD4 THAP10 THAP7 TMEM120B TRAPPC5 TTC23 TYMSOS ZBTB24 ZGPAT ZNF124 ZNF136 ZNF169 ZNF20 ZNF230 ZNF334 ZNF394 ZNF439 ZNF490 ZNF555 ZNF564 ZNF581 ZNF627 ZNF670 ZNF697 ZNF707 ZNRF2P1 ZSCAN26
Entrez ID		6687	23582
HPRD ID		04149	06156
Ensembl ID		ENSG00000197912
Uniprot IDs		Q9UQ90	O95273
PDB IDs		2QZ4	3AY5
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Nucleus Regulation Of Protein Import Into Nucleus Negative Regulation Of Wnt Signaling Pathway Regulation Of Cellular Process Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Viral Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of DNA Demethylation Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Regulation Of Protein Localization Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Cytokinesis Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Embryonic Placenta Development Transcription, DNA-templated Inflammatory Response Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Intracellular Transport RNA Metabolic Process RNA Biosynthetic Process Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting Phosphatidylserine Biosynthetic Process DNA Methylation Involved In Embryo Development Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Viral Process Response To Stimulus Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Intracellular Protein Transport RNA Processing Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Spindle Midzone Assembly Placenta Development Positive Regulation Of Protein Metabolic Process Phospholipid Scrambling Regulation Of Protein Transport	Gene Expression RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Metabolic Process Translational Termination Translational Elongation Cellular Protein Complex Disassembly Protein Complex Disassembly Regulation Of Cellular Process Translational Initiation MRNA Catabolic Process Cellular Process Negative Regulation Of Cell Cycle RNA Catabolic Process Translation Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Mitotic DNA Damage Checkpoint Cotranslational Protein Targeting To Membrane Protein Targeting To ER Viral Process Mitotic DNA Integrity Checkpoint Establishment Of Protein Localization To Endoplasmic Reticulum Negative Regulation Of Meiotic Cell Cycle Positive Regulation Of Histone H3-K36 Methylation Establishment Of Meiotic Spindle Orientation Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Protein Localization To Endoplasmic Reticulum Regulation Of Meiosis Cellular Protein Metabolic Process Myeloid Dendritic Cell Activation Involved In Immune Response Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Tagcloud ?		ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness	astrocyte astrocytes c6 cerebral challenge cns conditioned cortex designed distribution dynamic elucidate injection interactor lipopolysaccharide lps media neuroinflammation neuronal p29 pc12 pre silencing sirna splicing strategy strongly syf2 upregulation
Tagcloud (Difference) ?		ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness	astrocyte astrocytes c6 cerebral challenge cns conditioned cortex designed distribution dynamic elucidate injection interactor lipopolysaccharide lps media neuroinflammation neuronal p29 pc12 pre silencing sirna splicing strategy strongly syf2 upregulation
Tagcloud (Intersection) ?