SPG7 and PLSCR1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		SPG7	PLSCR1
Gene Name		spastic paraplegia 7 (pure and complicated autosomal recessive)	phospholipid scramblase 1
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane Mitochondrial Membrane	Nucleus Nucleolus Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Matrix Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding CD4 Receptor Binding
	Biological Process	Proteolysis Mitochondrion Organization Nervous System Development Anterograde Axon Cargo Transport	Phosphatidylserine Biosynthetic Process Apoptotic Process Acute-phase Response Positive Regulation Of Gene Expression Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NL PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SPATS1 STAMBP TRIM28	125 interactors: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf10 C10orf54 C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF3L CPSF6 CRK CRKL CRY1 CTBP1-AS2 CTSZ DAZAP2 DEF6 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM103A1 FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 IP6K2 KIAA1683 KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PRKCD PRR13 RASD1 RBL1 RERE RGS3 SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG TRAF4 TRIM42 VASP VPS37C YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF764
Entrez ID		6687	5359
HPRD ID		04149	08855
Ensembl ID		ENSG00000197912	ENSG00000188313
Uniprot IDs		Q9UQ90	B4DTE8 O15162
PDB IDs		2QZ4	1Y2A
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Localization To Nucleus Regulation Of Protein Import Into Nucleus Negative Regulation Of Wnt Signaling Pathway Regulation Of Cellular Process Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Viral Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of DNA Demethylation Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Regulation Of Protein Localization Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Cytokinesis Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Embryonic Placenta Development Transcription, DNA-templated Inflammatory Response Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Intracellular Transport RNA Metabolic Process RNA Biosynthetic Process Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting Phosphatidylserine Biosynthetic Process DNA Methylation Involved In Embryo Development Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Viral Process Response To Stimulus Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Intracellular Protein Transport RNA Processing Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Spindle Midzone Assembly Placenta Development Positive Regulation Of Protein Metabolic Process Phospholipid Scrambling Regulation Of Protein Transport	Regulation Of Nitrogen Compound Metabolic Process Organ Development RNA Metabolic Process Transcription, DNA-templated Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Developmental Process RNA Biosynthetic Process Multicellular Organismal Development Regulation Of Protein Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Response To Organic Substance ERBB Signaling Pathway Regulation Of Nucleic Acid-templated Transcription System Development Regulation Of RNA Biosynthetic Process Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Response To Growth Factor Cellular Macromolecule Biosynthetic Process Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Central Nervous System Development Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Development Pattern Specification Process Cellular Process Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Activation Of Protein Kinase Activity Platelet Activation
Tagcloud ?		ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Difference) ?		ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness	actions adaptor adding anchorage attenuation blocking colorectal crc crcs dephosphorylation effectors erks g1 ht29 led monoclonal np1 overexpressed phospholipid retinoblastoma scramblase serve shc src terminus trafficking treating tumorigenesis tumorigenic
Tagcloud (Intersection) ?