SPARC and HSPG2

Number of citations of the paper that reports this interaction (PubMedID 2745554)
77

Data Source:
HPRD (in vitro)

		SPARC	HSPG2
Description		secreted protein acidic and cysteine rich	heparan sulfate proteoglycan 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen	Extracellular Region Basement Membrane Extracellular Space Golgi Lumen Plasma Membrane Focal Adhesion Extracellular Matrix Neuron Projection Lysosomal Lumen Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding	Amyloid-beta Binding Integrin Binding Calcium Ion Binding Protein Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Collagen V Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Semicircular Canal Morphogenesis Regulation Of Synapse Organization	Angiogenesis Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Lipid Metabolic Process Receptor-mediated Endocytosis Inflammatory Response Negative Regulation Of Cell Adhesion Smoothened Signaling Pathway Brain Development Embryo Implantation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Negative Regulation Of Angiogenesis Cell Differentiation Animal Organ Regeneration Negative Regulation Of Neuron Apoptotic Process Circulatory System Development Negative Regulation Of Amyloid Fibril Formation
Pathways		Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors	Degradation of the extracellular matrix Degradation of the extracellular matrix Glycosaminoglycan-protein linkage region biosynthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Non-integrin membrane-ECM interactions ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Attachment and Entry Attachment and Entry Retinoid metabolism and transport Amyloid fiber formation Respiratory syncytial virus (RSV) attachment and entry RSV-host interactions Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Formation of the dystrophin-glycoprotein complex (DGC)
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Palifermin
Diseases			Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS		Stroke ( 32693751)	Atrial fibrillation ( 30061737) Cerebral microbleeds (lobar) ( 32913026) Height ( 28552196) PR interval ( 32439900)
Interacting Genes		26 interacting genes: COL11A1 COL13A1 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 TNC UBQLN1 VEGFA VHL XRCC6 ZNF579	33 interacting genes: APP ATF7IP ATN1 BMP1 CACNA1A CCN2 COL13A1 ECM1 FBLN1 FBLN2 FBN1 FGF2 FGF7 FGFBP1 FN1 GFI1B GRN HSP90AA1 ITGA2 ITGB1 LAMA1 MTDH NID1 NID2 PDGFA PDGFB PRELP PRPF40A SPARC TCAP TTR UBC VWA1
Entrez ID		6678	3339
HPRD ID		01631	00804
Ensembl ID		ENSG00000113140	ENSG00000142798
Uniprot IDs		P09486	P98160
PDB IDs		1BMO 1NUB 1SRA 2V53	3SH4 3SH5
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Collagen Trimer Platelet Alpha Granule Lumen Proteoglycan Binding Anatomical Structure Morphogenesis Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Animal Organ Morphogenesis Collagen Fibril Organization Anatomical Structure Formation Involved In Morphogenesis Response To Oxygen Levels Animal Organ Development Response To Hypoxia Protease Binding Angiogenesis Response To Decreased Oxygen Levels Regulation Of Blood Vessel Endothelial Cell Migration Collagen Type XI Trimer Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Blood Coagulation Regulation Of Hemostasis Blood Vessel Development Integrin Binding Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Motility Regulation Of Cell Adhesion Regulation Of Locomotion Platelet-derived Growth Factor Receptor Signaling Pathway Developmental Process Response To Stress Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Golgi Lumen Regulation Of Endothelial Cell Migration Secretory Granule Cell Migration Regulation Of Developmental Process Response To Wounding Negative Regulation Of Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Region Extracellular Space Basement Membrane Heparin Binding Collagen Binding Positive Regulation Of Cell Migration Integrin Binding Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Cell-matrix Adhesion Regulation Of Cell Motility Regulation Of Locomotion Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Platelet Alpha Granule Lumen Regulation Of Endothelial Cell Proliferation Chemoattractant Activity Growth Factor Activity Peptidase Activator Activity Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade Endoplasmic Reticulum Lumen Integrin-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Angiogenesis Positive Chemotaxis Positive Regulation Of Cell Communication Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Positive Regulation Of Endothelial Cell Migration Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Developmental Process Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Animal Organ Development
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