SPARC and COL11A1

Number of citations of the paper that reports this interaction (PubMedID 19542224)
57

Data Source:
BioGRID (pull down)

		SPARC	COL11A1
Description		secreted protein acidic and cysteine rich	collagen type XI alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Semicircular Canal Morphogenesis Regulation Of Synapse Organization	Cartilage Condensation Chondrocyte Development Heart Morphogenesis Proteoglycan Metabolic Process Visual Perception Sensory Perception Of Sound Collagen Fibril Organization Endodermal Cell Differentiation Tendon Development Inner Ear Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Cartilage Development Ventricular Cardiac Muscle Tissue Morphogenesis
Pathways		Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors	Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Non-integrin membrane-ECM interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases			Type XI collagenopathies, including: Stickler syndrome type 2; Stickler syndrome type 3; Otospondylomegaepiphyseal dysplasia (OSMED); Marshall syndrome; Weissenbacher-Zweymuller syndrome Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Stroke ( 32693751)	Bone mineral density change response to combined chemotherapy in acute lymphoblastic leukemia ( 29266176) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carpal tunnel syndrome ( 30833571) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Femoral neck bone mineral density ( 22504420) Glaucoma (primary angle closure) ( 27064256 22922875) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Height ( 28552196) Hip bone size ( 31053729) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Intertrochanteric region size ( 31053729) Lateral ventricle temporal horn volume ( 31530798) Open-angle glaucoma and optic cup area ( 29449654) Osteoarthritis (hip) ( 30374069) Protein quantitative trait loci ( 18464913) Spine bone size ( 31053729) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic juvenile idiopathic arthritis ( 27927641) Tinnitus ( 32970095) Triglyceride levels x loop diuretics use interaction ( 31806883) Trochanter size ( 31053729) Urate levels (BMI interaction) ( 25811787) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: COL11A1 COL13A1 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 TNC UBQLN1 VEGFA VHL XRCC6 ZNF579	6 interacting genes: APP DDR1 ITGAV SPARC TGM2 THBS1
Entrez ID		6678	1301
HPRD ID		01631	00375
Ensembl ID		ENSG00000113140	ENSG00000060718
Uniprot IDs		P09486	P12107 Q59HB5
PDB IDs		1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Collagen Trimer Platelet Alpha Granule Lumen Proteoglycan Binding Anatomical Structure Morphogenesis Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Animal Organ Morphogenesis Collagen Fibril Organization Anatomical Structure Formation Involved In Morphogenesis Response To Oxygen Levels Animal Organ Development Response To Hypoxia Protease Binding Angiogenesis Response To Decreased Oxygen Levels Regulation Of Blood Vessel Endothelial Cell Migration Collagen Type XI Trimer Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Blood Coagulation Regulation Of Hemostasis Blood Vessel Development Integrin Binding Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Motility Regulation Of Cell Adhesion Regulation Of Locomotion Platelet-derived Growth Factor Receptor Signaling Pathway Developmental Process Response To Stress Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Golgi Lumen Regulation Of Endothelial Cell Migration Secretory Granule Cell Migration Regulation Of Developmental Process Response To Wounding Negative Regulation Of Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Platelet Alpha Granule Extracellular Matrix Binding Platelet Alpha Granule Lumen Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin Binding Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Motility Cellular Response To Catecholamine Stimulus Positive Regulation Of Locomotion Response To Catecholamine Transforming Growth Factor Beta Binding Fibroblast Growth Factor Binding Cell Surface Apoptotic Cell Clearance Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Signal Transduction Wound Healing, Spreading Of Cells Fibronectin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Negative Regulation Of Lipid Transport Cell Adhesion Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Tube Morphogenesis Regulation Of Intracellular Signal Transduction Regulation Of Endocytosis Regulation Of Angiogenesis Extracellular Exosome Regulation Of Cell Migration Extracellular Region Regulation Of Vasculature Development Negative Regulation Of Endothelial Cell Proliferation External Side Of Plasma Membrane Regulation Of Sprouting Angiogenesis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Apoptotic Signaling Pathway Collagen Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Developmental Process Regulation Of Response To Calcium Ion
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