SPARC

Gene Name		secreted protein, acidic, cysteine-rich (osteonectin)
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Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Collagen Binding Extracellular Matrix Binding
	Biological Process	Ossification Negative Regulation Of Endothelial Cell Proliferation Platelet Degranulation Receptor-mediated Endocytosis Signal Transduction Heart Development Blood Coagulation Response To Gravity Response To Lead Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Platelet Activation Extracellular Matrix Organization Lung Development Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Cytokine Response To Peptide Hormone Response To Ethanol Response To Cadmium Ion Inner Ear Development Response To Glucocorticoid Response To CAMP Response To Calcium Ion Bone Development Cellular Response To Growth Factor Stimulus
Pathways		Scavenging by Class H Receptors Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS
Protein-protein Interactions		21 interactors: COL13A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 UBQLN1 VEGFA XRCC6 ZNF579
Entrez ID		6678
HPRD ID		01631
Ensembl ID		ENSG00000113140
Uniprot IDs		P09486
PDB IDs		1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Wound Healing Platelet Activation Response To Wounding Blood Coagulation Hemostasis Collagen Catabolic Process Locomotion Blood Vessel Development Platelet Degranulation Organ Morphogenesis Vasculature Development Collagen Metabolic Process Regulation Of Body Fluid Levels Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Response To Abiotic Stimulus Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Response To Hypoxia Cell Activation Tissue Development Response To Stress System Development Cellular Response To Growth Factor Stimulus Cell Migration Organ Development Bone Morphogenesis Response To Growth Factor Connective Tissue Development Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Collagen Fibril Organization Multicellular Organismal Development Anatomical Structure Development Vesicle-mediated Transport Endochondral Bone Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Exocytosis Response To Transforming Growth Factor Beta Skeletal System Development Regulation Of Blood Coagulation Positive Regulation Of Kidney Development Cartilage Development Involved In Endochondral Bone Morphogenesis Leukocyte Migration Developmental Process Bone Development
Tagcloud ?		aggregation chaperone chaperones combining concert culturing dependency divergent dnakj entirely ethanol exhibiting facilitated flask folding galactosidase grown hsps inoculation operon overexpressing overproduction pres2 prone shake simply supplementation upregulate yields