SPARC and COL13A1

Number of citations of the paper that reports this interaction (PubMedID 11956183)
0

Data Source:
HPRD (in vitro)

		SPARC	COL13A1
Description		secreted protein acidic and cysteine rich	collagen type XIII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen	Extracellular Region Collagen Trimer Collagen Type XIII Trimer Basement Membrane Endoplasmic Reticulum Lumen Plasma Membrane Membrane Extracellular Matrix Synapse Postsynaptic Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding	Protein Binding Heparin Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Semicircular Canal Morphogenesis Regulation Of Synapse Organization	Ossification Morphogenesis Of A Branching Structure Endochondral Ossification Cell Adhesion Cell-matrix Adhesion Cell Differentiation Cell-cell Adhesion
Pathways		Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors	Collagen degradation Collagen biosynthesis and modifying enzymes Integrin cell surface interactions Collagen chain trimerization
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Stroke ( 32693751)	Adverse response to drug ( 30420678) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Carboplatin disposition in epthelial ovarian cancer ( 29367611) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Early childhood aggressive behavior ( 26087016) Middle childhood and early adolescence aggressive behavior ( 26087016) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Optic disc size ( 31809533) Parkinson's disease ( 23793441) PR interval ( 32439900) Response to fenofibrate (total cholesterol levels) ( 27002377) Triglyceride levels in HIV infection ( 33109212) Ulcerative colitis ( 25082827) Upper eyelid morphology ( 29921221)
Interacting Genes		26 interacting genes: COL11A1 COL13A1 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 TNC UBQLN1 VEGFA VHL XRCC6 ZNF579	7 interacting genes: FN1 HSPG2 ITGA1 MTDH NID1 NID2 SPARC
Entrez ID		6678	1305
HPRD ID		01631	00383
Ensembl ID		ENSG00000113140	ENSG00000197467
Uniprot IDs		P09486	A0A2R8YGI3 A0A669KB16 A0A669KB28 A0A6E1W314 Q5TAT6
PDB IDs		1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Collagen Trimer Platelet Alpha Granule Lumen Proteoglycan Binding Anatomical Structure Morphogenesis Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Animal Organ Morphogenesis Collagen Fibril Organization Anatomical Structure Formation Involved In Morphogenesis Response To Oxygen Levels Animal Organ Development Response To Hypoxia Protease Binding Angiogenesis Response To Decreased Oxygen Levels Regulation Of Blood Vessel Endothelial Cell Migration Collagen Type XI Trimer Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Blood Coagulation Regulation Of Hemostasis Blood Vessel Development Integrin Binding Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Motility Regulation Of Cell Adhesion Regulation Of Locomotion Platelet-derived Growth Factor Receptor Signaling Pathway Developmental Process Response To Stress Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Golgi Lumen Regulation Of Endothelial Cell Migration Secretory Granule Cell Migration Regulation Of Developmental Process Response To Wounding Negative Regulation Of Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Collagen Binding Basement Membrane Cell-matrix Adhesion Extracellular Matrix Structural Constituent Extracellular Matrix Cell-substrate Adhesion Proteoglycan Binding Calcium Ion Binding Extracellular Matrix Binding Basement Membrane Organization Regulation Of Anatomical Structure Morphogenesis Cell Adhesion Regulation Of Vasculature Development Regulation Of Angiogenesis Platelet Alpha Granule Lumen Extracellular Exosome Extracellular Region Integrin-mediated Signaling Pathway Collagen V Binding Integrin Alpha1-beta1 Complex Regulation Of Developmental Process Negative Regulation Of Monocyte Activation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Calcium-independent Cell-matrix Adhesion Integrin Binding Extracellular Space Regulation Of Endothelial Cell Proliferation Positive Regulation Of Signal Transduction Collagen Binding Involved In Cell-matrix Adhesion Regulation Of Cell Population Proliferation Neural Crest Cell Migration Involved In Autonomic Nervous System Development Negative Regulation Of Cell Population Proliferation Phosphatase Activator Activity Intercellular Canaliculus Positive Regulation Of Cell Communication Regulation Of Cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signaling Fibrinogen Complex Regulation Of Cell-substrate Adhesion Regulation Of Basement Membrane Organization Laminin-1 Binding Semicircular Canal Morphogenesis Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Protein Complex Involved In Cell-matrix Adhesion
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