SOX2 and NR5A1

Number of citations of the paper that reports this interaction (PubMedID 12732652)
0

Data Source:
HPRD (in vitro)

		SOX2	NR5A1
Description		SRY-box transcription factor 2	nuclear receptor subfamily 5 group A member 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Nitric-oxide Synthase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Enzyme Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of DNA-templated Transcription Brain Development Response To Wounding Regulation Of Gene Expression Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Neuron Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Positive Regulation Of MAPK Cascade Response To Ethanol Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Response To Growth Factor Cellular Response To Hypoxia Negative Regulation Of Canonical Wnt Signaling Pathway Response To Oxygen-glucose Deprivation Neuronal Stem Cell Population Maintenance Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Myofibroblast Cell Apoptotic Process	Luteinization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Sex Determination Primary Sex Determination Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Tissue Development Positive Regulation Of Gene Expression Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Leydig Cell Differentiation Hormone Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Steroid Biosynthetic Process Maintenance Of Protein Location In Nucleus Sertoli Cell Differentiation Response To Gonadotropin-releasing Hormone Calcineurin-mediated Signaling Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2 Germ layer formation at gastrulation Formation of the anterior neural plate Formation of the anterior neural plate Formation of the posterior neural plate Formation of the posterior neural plate Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells Transcriptional regulation of testis differentiation
Drugs			(2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Phosphatidyl ethanol
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia	Premature ovarian failure 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Adult body size ( 32376654) Age-related nuclear cataracts ( 33311586) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Chronotype ( 30696823) Excessive hairiness ( 29895819) Eyebrow thickness ( 30248107) General risk tolerance (MTAG) ( 30643258) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Self-reported risk-taking behaviour ( 30181555) Toxoplasma gondii sag1 antibody levels ( 33204752)	Chronotype ( 30696823)
Interacting Genes		19 interacting genes: ALX4 CASP8 CDK1 CDX1 FZR1 HNF1B L3MBTL3 MAPK3 NFIC NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 TRIM26 UBR5 WWP2 XPO1	35 interacting genes: AR CATSPERT CKS1B CREBBP CTNNB1 CXXC1 EDF1 GATA4 GTF2B JUN MAPK1 NCK2 NCOA1 NFKB2 NFYA NR0B1 NRIP1 NTAQ1 PIAS1 PITX1 PNRC2 PROX1 RAD54L2 RFC5 SMARCD3 SOX2 SOX8 SOX9 SP1 TBX19 TEKT4 TRAPPC2 TRERF1 UBE2I ZNF653
Entrez ID		6657	2516
HPRD ID		08921	01702
Ensembl ID		ENSG00000181449	ENSG00000136931
Uniprot IDs		A0A0U3FYV6 P48431	F1D8R8 Q13285
PDB IDs		1O4X 2LE4 6T7B 6T90 6WX7 6WX8 6WX9 6YOV	1YOW 1ZDT 4QJR 4QK4 7KHT 8DAF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Proteolysis DNA Synthesis Involved In Mitotic DNA Replication Protein Modification Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Nucleocytoplasmic Transport Nucleoplasm Thymidine Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of RNA Metabolic Process Protein K11-linked Ubiquitination Protein Polyubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endodermal Cell Fate Specification Regulation Of Intracellular Protein Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Thymidine Metabolic Process Regulation Of Protein Localization To Nucleus Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Import Into Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Biosynthetic Process	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Binding Regulation Of Gene Expression Nucleoplasm Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cell Fate Commitment DNA-binding Transcription Factor Binding Gland Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Male Gonad Development Negative Regulation Of Biosynthetic Process Reproductive Structure Development Sequence-specific Double-stranded DNA Binding Transcription Coregulator Activity RNA Polymerase II Transcription Regulator Complex Gonad Development Animal Organ Development Pituitary Gland Development Glial Cell Fate Commitment Developmental Induction
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