SOX2 and ALX4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		SOX2	ALX4
Description		SRY-box transcription factor 2	ALX homeobox 4
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Nitric-oxide Synthase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Chromatin Organization Regulation Of DNA-templated Transcription Brain Development Response To Wounding Regulation Of Gene Expression Glial Cell Fate Commitment Pituitary Gland Development Adenohypophysis Development Positive Regulation Of Cell-cell Adhesion Neuron Differentiation Forebrain Development Somatic Stem Cell Population Maintenance Tissue Regeneration Positive Regulation Of MAPK Cascade Response To Ethanol Positive Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inner Ear Development Response To Growth Factor Cellular Response To Hypoxia Negative Regulation Of Canonical Wnt Signaling Pathway Response To Oxygen-glucose Deprivation Neuronal Stem Cell Population Maintenance Negative Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Myofibroblast Cell Apoptotic Process	Skeletal System Development Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Limb Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Digestive Tract Development Neuron Development Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development
Pathways		POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Deactivation of the beta-catenin transactivating complex Transcriptional regulation of pluripotent stem cells Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by MECP2 Germ layer formation at gastrulation Formation of the anterior neural plate Formation of the anterior neural plate Formation of the posterior neural plate Formation of the posterior neural plate Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia	Enlarged parietal foramina/cranium bifidum Frontonasal dysplasia
GWAS		Adult body size ( 32376654) Age-related nuclear cataracts ( 33311586) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Chronotype ( 30696823) Excessive hairiness ( 29895819) Eyebrow thickness ( 30248107) General risk tolerance (MTAG) ( 30643258) Monobrow ( 27182965) Night sleep phenotypes ( 27126917) Self-reported risk-taking behaviour ( 30181555) Toxoplasma gondii sag1 antibody levels ( 33204752)	Blood pressure measurement (high sodium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) ghrelin levels ( 33852427) Gout ( 22179738) Male-pattern baldness ( 27182965 29146897) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		19 interacting genes: ALX4 CASP8 CDK1 CDX1 FZR1 HNF1B L3MBTL3 MAPK3 NFIC NR5A1 OTUD7B POU2F1 POU5F1 SETD7 SUMO1 TRIM26 UBR5 WWP2 XPO1	14 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 IQUB LEF1 PARVG SOX10 SOX2
Entrez ID		6657	60529
HPRD ID		08921	05661
Ensembl ID		ENSG00000181449	ENSG00000052850
Uniprot IDs		A0A0U3FYV6 P48431	Q9H161
PDB IDs		1O4X 2LE4 6T7B 6T90 6WX7 6WX8 6WX9 6YOV	2M0C 8OSB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Proteolysis DNA Synthesis Involved In Mitotic DNA Replication Protein Modification Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Regulation Of Nucleocytoplasmic Transport Nucleoplasm Thymidine Biosynthetic Process Regulation Of Intracellular Transport Negative Regulation Of RNA Metabolic Process Protein K11-linked Ubiquitination Protein Polyubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Endodermal Cell Fate Specification Regulation Of Intracellular Protein Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Thymidine Metabolic Process Regulation Of Protein Localization To Nucleus Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Import Into Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Biosynthetic Process	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Regionalization DNA Binding Anterior/posterior Pattern Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Pattern Specification Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Anatomical Structure Morphogenesis Regulation Of RNA Metabolic Process Gland Development Regulation Of Nucleobase-containing Compound Metabolic Process Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Sequence-specific DNA Binding Transcription Cis-regulatory Region Binding Skeletal System Morphogenesis Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Embryonic Organ Morphogenesis Glossopharyngeal Nerve Morphogenesis Regulation Of Primary Metabolic Process Developmental Process Animal Organ Development Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Cellular Developmental Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Radial Glial Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Cranial Nerve Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Glial Cell Differentiation Nucleus System Development Morphogenesis Of An Epithelium RNA Polymerase II Transcription Regulator Complex
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