SOX2 and ALX4

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		SOX2	ALX4
Gene Name		SRY (sex determining region Y)-box 2	ALX homeobox 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Transcription Factor Complex	Nucleus Transcription Factor Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Positive Regulation Of Neuroblast Proliferation Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Response To Wounding Regulation Of Gene Expression Glial Cell Fate Commitment Forebrain Neuron Differentiation Pituitary Gland Development Adenohypophysis Development Cerebral Cortex Development Positive Regulation Of Cell-cell Adhesion Male Genitalia Development Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Olfactory Placode Formation Response To Retinoic Acid Somatic Stem Cell Maintenance Tissue Regeneration Inner Ear Morphogenesis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Tongue Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Pigment Biosynthetic Process Lung Alveolus Development Neuron Fate Commitment Inner Ear Development Diencephalon Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Equilibrioception Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye Epithelial Tube Branching Involved In Lung Morphogenesis Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance	Skeletal System Development Hair Follicle Development Transcription, DNA-templated Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Development Embryonic Skeletal System Morphogenesis Palate Development
Pathways		Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: ALX4 CDX1 FZR1 NR5A1 POU2F1 POU5F1 SETD7 SUMO1 XPO1	12 interactors: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2
Entrez ID		6657	60529
HPRD ID		08921	05661
Ensembl ID		ENSG00000181449	ENSG00000052850
Uniprot IDs		P48431	Q9H161
PDB IDs		1O4X 2LE4	2M0C
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Protein Localization To Nucleus Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Developmental Induction Transcription From RNA Polymerase II Promoter Tissue Development Organ Development Regulation Of Protein Catabolic Process RNA Metabolic Process Anatomical Structure Development Lens Development In Camera-type Eye Cellular Macromolecule Biosynthetic Process Protein Localization To Organelle Palate Development Macromolecule Biosynthetic Process Developmental Process Ribosomal Small Subunit Export From Nucleus Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway BMP Signaling Pathway Involved In Heart Induction Negative Regulation Of Gene Silencing By MiRNA Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Methylation-dependent Chromatin Silencing Primary Sex Determination PML Body Organization Cardiac Cell Fate Determination Embryonic Morphogenesis System Development BMP Signaling Pathway Involved In Heart Development	Organ Development Organ Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryo Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Pattern Specification Process System Development Embryonic Organ Development Anterior/posterior Pattern Specification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Multicellular Organismal Development Embryonic Organ Morphogenesis Regulation Of Gene Expression Anatomical Structure Development Anatomical Structure Morphogenesis Gene Expression Embryonic Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Developmental Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Tissue Development Embryonic Skeletal System Morphogenesis Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Tube Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Mesenchyme Development Gland Development Morphogenesis Of An Epithelium Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Stem Cell Development
Tagcloud ?		adipogenic af afmsc afmscs amniotic cd326 cd90 chaperones chondrogenic classes eighteen f fibroblast fluid hc1 hc2 multipotent osteogenic phenotypes pin predominant preparations proteasomes proteomic regardless regenerative slight spots ssea	associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53
Tagcloud (Difference) ?		adipogenic af afmsc afmscs amniotic cd326 cd90 chaperones chondrogenic classes eighteen f fibroblast fluid hc1 hc2 multipotent osteogenic phenotypes pin predominant preparations proteasomes proteomic regardless regenerative slight spots ssea	associating candidates cooccur cooperation crebbp driver exclusive forward foxr2 gli gli1 gnp gnps granule hedgehog medulloblastoma mutagenesis mutually nih3t3 oncogenes screen shh sonic strengthening subtype tended tgif2 transposon trp53
Tagcloud (Intersection) ?