SOX2 and POU5F1

Number of citations of the paper that reports this interaction (PMID 12923055)
78

Data Source:
HPRD (in vitro)

		SOX2	POU5F1
Gene Name		SRY (sex determining region Y)-box 2	POU class 5 homeobox 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Nuclear Transcription Factor Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Eye Development Endodermal Cell Fate Specification Positive Regulation Of Neuroblast Proliferation Chromatin Organization Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Response To Wounding Regulation Of Gene Expression Glial Cell Fate Commitment Forebrain Neuron Differentiation Pituitary Gland Development Adenohypophysis Development Cerebral Cortex Development Positive Regulation Of Cell-cell Adhesion Male Genitalia Development Positive Regulation Of Epithelial Cell Differentiation Forebrain Development Olfactory Placode Formation Response To Retinoic Acid Somatic Stem Cell Maintenance Tissue Regeneration Inner Ear Morphogenesis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Tongue Development Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Pigment Biosynthetic Process Lung Alveolus Development Neuron Fate Commitment Inner Ear Development Diencephalon Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Equilibrioception Retina Morphogenesis In Camera-type Eye Lens Induction In Camera-type Eye Epithelial Tube Branching Involved In Lung Morphogenesis Response To Growth Factor Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance	Endodermal Cell Fate Specification Blastocyst Development BMP Signaling Pathway Involved In Heart Induction Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Somatic Stem Cell Maintenance Positive Regulation Of Catenin Import Into Nucleus MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Cell Fate Determination Negative Regulation Of Gene Silencing By MiRNA Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway Regulation Of Methylation-dependent Chromatin Silencing
Pathways		Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS			Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425 21801394)
Protein-Protein Interactions		9 interactors: ALX4 CDX1 FZR1 NR5A1 POU2F1 POU5F1 SETD7 SUMO1 XPO1	14 interactors: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH MNAT1 NR0B1 SOX10 SOX2 SOX8 WDR5 WWP2
Entrez ID		6657	5460
HPRD ID		08921	01252
Ensembl ID		ENSG00000181449	ENSG00000204531
Uniprot IDs		P48431	D2IYK3 M1S623 Q01860
PDB IDs		1O4X 2LE4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Protein Localization To Nucleus Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Developmental Induction Transcription From RNA Polymerase II Promoter Tissue Development Organ Development Regulation Of Protein Catabolic Process RNA Metabolic Process Anatomical Structure Development Lens Development In Camera-type Eye Cellular Macromolecule Biosynthetic Process Protein Localization To Organelle Palate Development Macromolecule Biosynthetic Process Developmental Process Ribosomal Small Subunit Export From Nucleus Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway BMP Signaling Pathway Involved In Heart Induction Negative Regulation Of Gene Silencing By MiRNA Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Methylation-dependent Chromatin Silencing Primary Sex Determination PML Body Organization Cardiac Cell Fate Determination Embryonic Morphogenesis System Development BMP Signaling Pathway Involved In Heart Development	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Reproductive Structure Development Reproductive System Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Cellular Nitrogen Compound Metabolic Process Sex Differentiation Regulation Of Cell Death System Development RNA Metabolic Process Nitrogen Compound Metabolic Process Developmental Process Involved In Reproduction Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Cellular Macromolecule Biosynthetic Process Male Sex Differentiation Positive Regulation Of Cell Proliferation Multicellular Organismal Development Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Proliferation
Tagcloud ?		adipogenic af afmsc afmscs amniotic cd326 cd90 chaperones chondrogenic classes eighteen f fibroblast fluid hc1 hc2 multipotent osteogenic phenotypes pin predominant preparations proteasomes proteomic regardless regenerative slight spots ssea	catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Difference) ?		adipogenic af afmsc afmscs amniotic cd326 cd90 chaperones chondrogenic classes eighteen f fibroblast fluid hc1 hc2 multipotent osteogenic phenotypes pin predominant preparations proteasomes proteomic regardless regenerative slight spots ssea	catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Intersection) ?