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SOX2
Gene Name
SRY (sex determining region Y)-box 2
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Nuclear Transcription Factor Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Chromatin Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
MiRNA Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Osteoblast Differentiation
Eye Development
Endodermal Cell Fate Specification
Positive Regulation Of Neuroblast Proliferation
Chromatin Organization
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Cell Cycle Arrest
Response To Wounding
Regulation Of Gene Expression
Glial Cell Fate Commitment
Forebrain Neuron Differentiation
Pituitary Gland Development
Adenohypophysis Development
Cerebral Cortex Development
Positive Regulation Of Cell-cell Adhesion
Male Genitalia Development
Positive Regulation Of Epithelial Cell Differentiation
Forebrain Development
Olfactory Placode Formation
Response To Retinoic Acid
Somatic Stem Cell Maintenance
Tissue Regeneration
Inner Ear Morphogenesis
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of MAPK Cascade
Tongue Development
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pigment Biosynthetic Process
Lung Alveolus Development
Neuron Fate Commitment
Inner Ear Development
Diencephalon Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Detection Of Mechanical Stimulus Involved In Equilibrioception
Retina Morphogenesis In Camera-type Eye
Lens Induction In Camera-type Eye
Epithelial Tube Branching Involved In Lung Morphogenesis
Response To Growth Factor
Negative Regulation Of Canonical Wnt Signaling Pathway
Neuronal Stem Cell Maintenance
Pathways
Transcriptional regulation of pluripotent stem cells
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS
Protein-protein Interactions
9 interactors:
ALX4
CDX1
FZR1
NR5A1
POU2F1
POU5F1
SETD7
SUMO1
XPO1
Entrez ID
6657
HPRD ID
08921
Ensembl ID
ENSG00000181449
Uniprot IDs
P48431
PDB IDs
1O4X
2LE4
Enriched GO Terms of Interacting Partners
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Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Gene Expression
Protein Localization To Nucleus
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Gene Expression
Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Developmental Induction
Transcription From RNA Polymerase II Promoter
Tissue Development
Organ Development
Regulation Of Protein Catabolic Process
RNA Metabolic Process
Anatomical Structure Development
Lens Development In Camera-type Eye
Cellular Macromolecule Biosynthetic Process
Protein Localization To Organelle
Palate Development
Macromolecule Biosynthetic Process
Developmental Process
Ribosomal Small Subunit Export From Nucleus
Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway
BMP Signaling Pathway Involved In Heart Induction
Negative Regulation Of Gene Silencing By MiRNA
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Regulation Of Methylation-dependent Chromatin Silencing
Primary Sex Determination
PML Body Organization
Cardiac Cell Fate Determination
Embryonic Morphogenesis
System Development
BMP Signaling Pathway Involved In Heart Development
Tagcloud
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adipogenic
af
afmsc
afmscs
amniotic
cd326
cd90
chaperones
chondrogenic
classes
eighteen
f
fibroblast
fluid
hc1
hc2
multipotent
osteogenic
phenotypes
pin
predominant
preparations
proteasomes
proteomic
regardless
regenerative
slight
spots
ssea