RHOH and ARHGDIG

Number of citations of the paper that reports this interaction (PMID 11809807)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RHOH	ARHGDIG
Gene Name		ras homolog family member H	Rho GDP dissociation inhibitor (GDI) gamma
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane	Cytosol Membrane Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	GTPase Inhibitor Activity Protein Binding GTP Binding Rho GTPase Binding Kinase Inhibitor Activity	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity
	Biological Process	Regulation Of Transcription, DNA-templated Small GTPase Mediated Signal Transduction T Cell Differentiation Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Activation Regulation Of Small GTPase Mediated Signal Transduction	Negative Regulation Of Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Regulation Of Protein Localization Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Graves' disease ( 21841780)
Protein-Protein Interactions		8 interactors: ARHGDIA ARHGDIB ARHGDIG GDI1 KCNH2 LRIF1 TGFBR1 UTP14A	8 interactors: CDC42 CEP170P1 KXD1 RAC1 RHOA RHOB RHOG RHOH
Entrez ID		399	398
HPRD ID		03616	04163
Ensembl ID			ENSG00000242173
Uniprot IDs		Q15669 Q6ICP4	F1T0H7 Q99819
PDB IDs
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Rho Protein Signal Transduction Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Adhesion Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Negative Regulation Of Axonogenesis Positive Regulation Of Hydrolase Activity Negative Regulation Of Potassium Ion Export Regulation Of Cell Morphogenesis Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Heart Rate By Hormone Negative Regulation Of Neuron Projection Development Regulation Of Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Regulation Of Axonogenesis Regulation Of Cellular Component Movement Negative Regulation Of Cell Differentiation Regulation Of Signaling Negative Regulation Of Neuron Differentiation Negative Regulation Of Protein Targeting To Membrane Signal Transduction Regulation Of Cell Development Positive Regulation Of Metabolic Process Parathyroid Gland Development Peptidyl-histidine Phosphorylation Regulation Of Heart Rate By Chemical Signal Signaling Regulation Of Intracellular Protein Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of Cell Projection Organization Potassium Ion Export Endothelial Cell Activation Negative Regulation Of Neurogenesis Pathway-restricted SMAD Protein Phosphorylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Potassium Ion Transmembrane Transport	Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Hemostasis Axonogenesis Platelet Activation Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Neuron Projection Morphogenesis Cell Activation Response To Wounding Rho Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Neuron Projection Development Regulation Of Intracellular Signal Transduction Cell Projection Morphogenesis Cell Part Morphogenesis Intracellular Signal Transduction Neuron Development Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Morphogenesis Regulation Of Cell Projection Assembly Neuron Differentiation Cell Projection Organization Regulation Of Cell Projection Organization Locomotion Positive Regulation Of Cell Morphogenesis Involved In Differentiation Actin Cytoskeleton Organization Regulation Of Signal Transduction Actin Filament-based Process Movement Of Cell Or Subcellular Component Cell-cell Junction Organization Generation Of Neurons Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Ras Protein Signal Transduction Regulation Of Signaling Neurogenesis Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Development Cell Migration Response To External Stimulus Substantia Nigra Development Positive Regulation Of Cell Projection Organization Cell Differentiation
Tagcloud ?		ar autosomal broaden cutaneous deficiencies deficiency discovery epidermodysplasia ercc3 etiology ev ever1 ever2 exome fungal homozygous hpvs infections kindreds manifestations mst1 otherwise profound recessive siblings thirds tumoral unrelated verruciformis
Tagcloud (Difference) ?		ar autosomal broaden cutaneous deficiencies deficiency discovery epidermodysplasia ercc3 etiology ev ever1 ever2 exome fungal homozygous hpvs infections kindreds manifestations mst1 otherwise profound recessive siblings thirds tumoral unrelated verruciformis
Tagcloud (Intersection) ?