RHOH and ARHGDIB

Number of citations: 66 (PubMedID 11809807)
Data Source: BioGRID (affinity chromatography technology), HPRD (two hybrid, in vitro, in vivo)

		RHOH	ARHGDIB
Name		ras homolog family member H	Rho GDP dissociation inhibitor beta
Structure		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Plasma Membrane Membrane	Cytoplasm Cytosol Cytoskeleton Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding Kinase Inhibitor Activity Protein Kinase Binding Small GTPase Binding	GTPase Activity Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction T Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Mast Cell Activation Positive Regulation Of T Cell Differentiation	Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Cellular Response To Redox State Negative Regulation Of Trophoblast Cell Migration
Pathways		RHOH GTPase cycle	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle
GWAS		Graves' disease ( 21841780 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Metabolite levels ( 23823483 ) Multiple sclerosis ( 31604244 ) Pre-treatment viral load in HIV-1 infection ( 31219150 )	No GWAS studies recorded
Interacting Genes		23 interacting genes: ARHGDIA ARHGDIB ARHGDIG BANP CCNH FAM90A1 GDI1 IQUB ITGB1BP1 KANK2 KCNH2 LRIF1 MBLAC1 MTX2 PLEKHA7 RIPPLY1 SCNM1 SORL1 SUOX TCF19 TGFBR1 UTP14A XPNPEP1	14 interacting genes: ANKRD1 APP CASP3 CDC42 CEBPA EZR RAC1 RAC2 RAC3 RHOA RHOH UBE3A UFM1 VAV1
Entrez ID		399	397
HPRD ID		03616	04162
Ensembl ID		ENSG00000168421	ENSG00000111348
Uniprot IDs		Q15669 Q6ICP4	P52566
PDB IDs		Not available	1DS6 5H1D
GO Terms Enriched among Interactors		Rho GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Targeting To Membrane Rho Protein Signal Transduction	Intracellular Signal Transduction Intracellular Signaling Cassette Actin Filament Organization Small GTPase-mediated Signal Transduction Supramolecular Fiber Organization Establishment Or Maintenance Of Cell Polarity Actin Cytoskeleton Organization Actin Filament-based Process Regulation Of Immune System Process Cortical Cytoskeleton Organization Regulation Of Cell Adhesion GTPase Activity Chemotaxis Signal Transduction Regulation Of Actin Cytoskeleton Organization Locomotion GTP Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction G Protein Activity Regulation Of Actin Filament-based Process Establishment Of Epithelial Cell Apical/basal Polarity NADPH Oxidase Complex Regulation Of Cell Projection Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-substrate Adhesion Respiratory Burst Cerebral Cortex GABAergic Interneuron Development Cellular Developmental Process Establishment Of Apical/basal Cell Polarity Regulation Of Leukocyte Migration Postsynapse Endocytosis Polarized Epithelial Cell Differentiation Protein Kinase Binding Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Cell Periphery Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Protein Metabolic Process Developmental Process Positive Regulation Of Cell Adhesion Establishment Of Epithelial Cell Polarity Regulation Of Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Vesicle-mediated Transport Response To Cytokine Positive Regulation Of Lamellipodium Organization Regulation Of Synapse Organization