RHOH and PLEKHA7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RHOH	PLEKHA7
Description		ras homolog family member H	pleckstrin homology domain containing A7
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Plasma Membrane Membrane	Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Zonula Adherens Cell Junction Pore Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding Kinase Inhibitor Activity Protein Kinase Binding Small GTPase Binding	Protein Binding Delta-catenin Binding
	Biological Process	Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction T Cell Differentiation Negative Regulation Of Canonical NF-kappaB Signal Transduction Mast Cell Activation Positive Regulation Of T Cell Differentiation	Cell-cell Adhesion Mediated By Cadherin Zonula Adherens Maintenance Pore Complex Assembly Epithelial Cell-cell Adhesion Cell-cell Adhesion
Pathways		RHOH GTPase cycle
Drugs
Diseases
GWAS		Graves' disease ( 21841780) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pre-treatment viral load in HIV-1 infection ( 31219150)	Blood pressure ( 21909110) Blood protein levels ( 30072576) Body mass index ( 26426971) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618452 27841878 19430479 28739976) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Glaucoma (primary angle closure) ( 22922875 27064256) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 31959993 29617998 29785010 30054594) Macular thickness ( 30535121) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Microalbuminuria in type 1 diabetes ( 31537649) Systolic blood pressure ( 30578418 28739976 27841878 27618452 19430479) Systolic blood pressure change trajectory ( 27980656) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		23 interacting genes: ARHGDIA ARHGDIB ARHGDIG BANP CCNH FAM90A1 GDI1 IQUB ITGB1BP1 KANK2 KCNH2 LRIF1 MBLAC1 MTX2 PLEKHA7 RIPPLY1 SCNM1 SORL1 SUOX TCF19 TGFBR1 UTP14A XPNPEP1	20 interacting genes: B9D2 CCHCR1 CCNDBP1 FAM228A GRB2 HOMEZ HSF2BP IGFBP6 IGFL2 LZTS1 NEK6 PIBF1 PICK1 PPL RDH12 RHOH STMN3 TRAF4 TSGA10 ZMAT5
Entrez ID		399	144100
HPRD ID		03616	15142
Ensembl ID		ENSG00000168421	ENSG00000166689
Uniprot IDs		Q15669 Q6ICP4	A0A8V8TMS3 E9PKC0 Q6IQ23
PDB IDs			7KJO 7KJZ 7KK7
Enriched GO Terms of Interacting Partners?		Rho GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Negative Regulation Of Protein Targeting To Membrane Rho Protein Signal Transduction
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