RHOH and KCNH2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		RHOH	KCNH2
Gene Name		ras homolog family member H	potassium channel, voltage gated eag related subfamily H, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane	Nuclear Envelope Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface
	Molecular Function	GTPase Inhibitor Activity Protein Binding GTP Binding Rho GTPase Binding Kinase Inhibitor Activity	Phosphorelay Sensor Kinase Activity Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Scaffold Protein Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Regulation Of Transcription, DNA-templated Small GTPase Mediated Signal Transduction T Cell Differentiation Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Mast Cell Activation Regulation Of Small GTPase Mediated Signal Transduction	Phosphorelay Signal Transduction System Regulation Of Heart Rate By Hormone Synaptic Transmission Signal Transduction By Phosphorylation Cellular Response To Drug Regulation Of Membrane Potential Potassium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Potassium Ion Transmembrane Transport Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Repolarization During Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Export
Pathways		Rho GTPase cycle Signaling by Rho GTPases	Potassium Channels Voltage gated Potassium channels
Drugs			Dofetilide Amsacrine Ibutilide Terfenadine Prazosin Sotalol Doxazosin Cisapride Astemizole Verapamil Thioridazine Quinidine Pimozide Miconazole Amiodarone Carvedilol Terazosin Propafenone Halofantrine Dronedarone Sertindole
Diseases
GWAS		Graves' disease ( 21841780)	Electrocardiographic traits ( 20062061 20062063) QT interval ( 23166209 19305408 19305409)
Protein-Protein Interactions		8 interactors: ARHGDIA ARHGDIB ARHGDIG GDI1 KCNH2 LRIF1 TGFBR1 UTP14A	10 interactors: ALG10 ALG10B CDC73 KCNE1 KCNE2 NDUFS6 PRKACA RHOH YWHAE YWHAH
Entrez ID		399	3757
HPRD ID		03616	01069
Ensembl ID			ENSG00000055118
Uniprot IDs		Q15669 Q6ICP4	Q12809 Q15BH2
PDB IDs			1BYW 1UJL 2L0W 2L1M 2L4R 2LE7 4HP9 4HQA
Enriched GO Terms of Interacting Partners?		Ras Protein Signal Transduction Rho Protein Signal Transduction Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Adhesion Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Negative Regulation Of Axonogenesis Positive Regulation Of Hydrolase Activity Negative Regulation Of Potassium Ion Export Regulation Of Cell Morphogenesis Regulation Of Catalytic Activity Regulation Of Cell Projection Organization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Heart Rate By Hormone Negative Regulation Of Neuron Projection Development Regulation Of Signal Transduction Regulation Of Cell Adhesion Negative Regulation Of Cell Projection Organization Regulation Of Axonogenesis Regulation Of Cellular Component Movement Negative Regulation Of Cell Differentiation Regulation Of Signaling Negative Regulation Of Neuron Differentiation Negative Regulation Of Protein Targeting To Membrane Signal Transduction Regulation Of Cell Development Positive Regulation Of Metabolic Process Parathyroid Gland Development Peptidyl-histidine Phosphorylation Regulation Of Heart Rate By Chemical Signal Signaling Regulation Of Intracellular Protein Transport Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cell Communication Signal Transduction By Phosphorylation Positive Regulation Of Cell Projection Organization Potassium Ion Export Endothelial Cell Activation Negative Regulation Of Neurogenesis Pathway-restricted SMAD Protein Phosphorylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Membrane Repolarization Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Potassium Ion Transmembrane Transport	Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cardiac Conduction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Regulation Of Heart Rate Action Potential Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Heart Contraction Regulation Of Potassium Ion Transmembrane Transport Regulation Of Potassium Ion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Striated Muscle Contraction Potassium Ion Export Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Protein N-linked Glycosylation Ventricular Cardiac Muscle Cell Action Potential Regulation Of Muscle Contraction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Substantia Nigra Development Positive Regulation Of Intracellular Transport Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Transport Dolichol-linked Oligosaccharide Biosynthetic Process Neural Nucleus Development Positive Regulation Of Mitochondrion Organization Protein Glycosylation Macromolecule Glycosylation Glycosylation Apoptotic Signaling Pathway Glucocorticoid Catabolic Process Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Glycoprotein Biosynthetic Process Midbrain Development Carbohydrate Metabolic Process Regulation Of Intracellular Transport
Tagcloud ?		ar autosomal broaden cutaneous deficiencies deficiency discovery epidermodysplasia ercc3 etiology ev ever1 ever2 exome fungal homozygous hpvs infections kindreds manifestations mst1 otherwise profound recessive siblings thirds tumoral unrelated verruciformis	1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Difference) ?		ar autosomal broaden cutaneous deficiencies deficiency discovery epidermodysplasia ercc3 etiology ev ever1 ever2 exome fungal homozygous hpvs infections kindreds manifestations mst1 otherwise profound recessive siblings thirds tumoral unrelated verruciformis	1c currents eag eag1 elk erg erg1 governed heag1 herg imbalance immuno itim kcnh1 kv10 kv11 kv12 nothing phosphatases pp1 prototypes ptp ptpn6 qt shp src40 subfamilies superfamily underlie
Tagcloud (Intersection) ?