SNRPN and CTBP1

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		SNRPN	CTBP1
Gene Name		small nuclear ribonucleoprotein polypeptide N	C-terminal binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex U1 SnRNP U2 SnRNP Small Nuclear Ribonucleoprotein Complex	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Transcriptional Repressor Complex
	Molecular Function	RNA Binding Protein Binding	RNA Polymerase II Transcription Corepressor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Protein Domain Specific Binding Protein Homodimerization Activity NAD Binding Repressing Transcription Factor Binding
	Biological Process	RNA Splicing Response To Hormone	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Phosphorylation Golgi Organization Negative Regulation Of Cell Proliferation Viral Genome Replication Positive Regulation Of Histone Deacetylation Negative Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated White Fat Cell Differentiation Regulation Of Cell Cycle Oxidation-reduction Process Negative Regulation Of Histone H4 Acetylation Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification
Pathways			APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Pulmonary function ( 17903307)
Protein-Protein Interactions		13 interactors: ARL4D CTBP1 FBL GAR1 GEMIN2 GTF2I KEAP1 LRIF1 MAFG RBFOX1 SH3GL3 SNRPD3 TP53	83 interactors: ACTL6B APC ARNT2 ATXN1L BCAS3 BCL3 BMPR2 BRCA1 CBX4 CDC23 CEP68 CHD3 CREBBP CRY2 CTBP2 CTNNA1 DGCR6 DMRTB1 EEF1D ELAC2 ELK3 EP300 FOXP1 FOXP2 FUNDC1 GTF2B HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC9 HEMGN HIC1 HIST3H3 HOXB5 HTT IKZF1 IKZF2 KAT2B KDM1A KLF12 KLF3 LCOR LCORL LNX1 MAPK9 MARCH10 MECOM NME2 NOL4 NOL4L NOS1 NRIP1 ORC4 PIAS2 PLCB1 PNN PRKAA1 RAI2 RB1 RBBP5 RBBP8 RCOR1 RNF111 SIN3A SNRPN SOBP SPEN TBP TCF4 TCF7L2 TERF2 TERF2IP TGIF1 THAP11 TSHZ3 ZBP1 ZBTB18 ZEB1 ZEB2 ZFPM2 ZNF219
Entrez ID		6638	1487
HPRD ID		01653	04015
Ensembl ID		ENSG00000128739	ENSG00000159692
Uniprot IDs		P63162	Q13363
PDB IDs			1MX3
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression Ribonucleoprotein Complex Biogenesis Positive Regulation Of Histone Deacetylation Positive Regulation Of Protein Deacetylation Transcription, DNA-templated NcRNA Metabolic Process RNA Biosynthetic Process Regulation Of Histone Deacetylation Spliceosomal SnRNP Assembly Regulation Of Epidermal Cell Differentiation Regulation Of Protein Deacetylation Regulation Of Epidermis Development Histone Glutamine Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Positive Regulation Of Histone Modification RNA Splicing Transcription From RNA Polymerase II Promoter Negative Regulation Of Macromitophagy Transition Between Slow And Fast Fiber Oligodendrocyte Apoptotic Process Peptidyl-glutamine Methylation Cellular Macromolecule Biosynthetic Process MRNA Processing Macromolecule Biosynthetic Process Negative Regulation Of Helicase Activity RRNA Processing Regulation Of Histone Modification SnoRNA Metabolic Process Proteasomal Ubiquitin-independent Protein Catabolic Process RRNA Metabolic Process In Utero Embryonic Development Cellular Metabolic Process Regulation Of Epithelial Cell Differentiation MRNA Metabolic Process Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process RNA Processing Mitochondrial DNA Repair Ribonucleoprotein Complex Assembly Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Ribosome Biogenesis	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Chromosome Organization Positive Regulation Of Metabolic Process Developmental Process Chromatin Modification Embryo Development Transcription From RNA Polymerase II Promoter Anatomical Structure Development Chromatin Organization Histone H4 Deacetylation Regulation Of Cell Differentiation Organelle Organization Organ Development Metabolic Process Regulation Of Cellular Process System Development
Tagcloud ?		allelic biallelic blastocyst blastomere blastomeres determines discounting elucidation establishment extension f1 germ h19 igf2 igf2r imprinted imprinting manifest modes monoallelic possibility postimplantation pregastrulation preimplantation primer raises reciprocal uniform utilizing	adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate
Tagcloud (Difference) ?		allelic biallelic blastocyst blastomere blastomeres determines discounting elucidation establishment extension f1 germ h19 igf2 igf2r imprinted imprinting manifest modes monoallelic possibility postimplantation pregastrulation preimplantation primer raises reciprocal uniform utilizing	adenine bik consists corepressor corepressors ctbp2 ctbps deacetylases dehydrogenase dinucleotide duplicative dysregulation e1a encodes exert hdac hdacs invertebrate methyltransferases nicotinamide nonetheless noxa partners perform puma repress repression vertebrate
Tagcloud (Intersection) ?