SNRPN and GEMIN2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		SNRPN	GEMIN2
Description		small nuclear ribonucleoprotein polypeptide N	gem nuclear organelle associated protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP U1 SnRNP U2 SnRNP U4 SnRNP Cytoplasm Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Prespliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Cajal Bodies
	Molecular Function	RNA Binding Protein Binding SnRNP Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Splicing	Spliceosomal Complex Assembly RNA Splicing, Via Transesterification Reactions Spliceosomal SnRNP Assembly MRNA Processing RNA Splicing Protein-containing Complex Assembly
Pathways		mRNA Splicing - Major Pathway	snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Aspartate aminotransferase levels ( 31219225) Carotid plaque burden ( 28282560) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Obesity-related traits ( 23251661) Panic disorder ( 31712720) Periodontal disease related phenotype (PCT5) ( 26962152) Periodontitis (DPAL) ( 24024966) Pulmonary function ( 17903307)	Vitamin D levels ( 28757204)
Interacting Genes		23 interacting genes: ARL4D BAG4 CD2BP2 CEP55 CFTR CTBP1 DMRTB1 EIF4ENIF1 EXOSC8 FBL FOXP1 GEMIN2 GTF2I KEAP1 LRIF1 MAFG RBFOX1 RBPMS SH3GL3 SHANK3 SNRPA TFIP11 TP53	33 interacting genes: BEND7 DDX20 DHX9 FBXO7 GEMIN5 HOXD10 IKBKG INCA1 KPNA6 MEOX1 MTNR1A NUFIP1 PAX6 PSMB1 RN7SL1 RNU1-1 RNU2-1 RPP14 SMN1 SMN2 SNRNP70 SNRPD1 SNRPD2 SNRPD3 SNRPN SPG21 SRSF1 SRSF2 SRSF3 SRSF4 STXBP2 STXBP3 U2AF2
Entrez ID		6638	8487
HPRD ID		01653	03999
Ensembl ID		ENSG00000128739	ENSG00000092208
Uniprot IDs		P63162 X5DP00	A0A8J9FJK1 A0A8J9FN78 O14893
PDB IDs		5MF9 8TBP	2LEH 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU
Enriched GO Terms of Interacting Partners?		Nucleus RNA Processing MRNA Metabolic Process Identical Protein Binding RNA Metabolic Process Nucleoplasm RNA Polymerase II-specific DNA-binding Transcription Factor Binding TFIID-class Transcription Factor Complex Binding RNA Splicing MRNA Processing Core Promoter Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein-folding Chaperone Binding	RNA Splicing MRNA Processing SMN-Sm Protein Complex Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions RNA Processing MRNA Metabolic Process Spliceosomal SnRNP Assembly RNA Metabolic Process MRNA Splicing, Via Spliceosome U1 SnRNP Spliceosomal Complex Assembly RNA Binding U2 SnRNP SMN Complex U4 SnRNP Nucleoplasm Nucleic Acid Metabolic Process Gemini Of Cajal Bodies Regulation Of MRNA Processing Small Nuclear Ribonucleoprotein Complex Protein-containing Complex Assembly Spliceosomal Complex U5 SnRNP Commitment Complex Regulation Of MRNA Splicing, Via Spliceosome PICln-Sm Protein Complex Protein-containing Complex Organization Nucleobase-containing Compound Metabolic Process 7-methylguanosine Cap Hypermethylation MRNA Binding Catalytic Step 2 Spliceosome U4/U6 X U5 Tri-snRNP Complex Regulation Of RNA Splicing Methylosome Sequence-specific MRNA Binding Regulation Of MRNA Metabolic Process Nucleus U2-type Prespliceosome Nuclear Body DNA-templated Transcription Termination Precatalytic Spliceosome Ribonucleoprotein Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Tertiary Granule Nucleic Acid Binding Cellular Response To Cytokine Stimulus U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Cytoplasmic Ribonucleoprotein Granule
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