PTCH1 and TMPRSS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTCH1	TMPRSS2
Description		patched 1	transmembrane serine protease 2
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Cilium Membrane Midbody Endocytic Vesicle Membrane Dendritic Growth Cone Axonal Growth Cone Apical Part Of Cell Postsynaptic Membrane Perinuclear Region Of Cytoplasm Ciliary Membrane	Extracellular Region Nucleoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein-containing Complex Binding Hedgehog Family Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Cell Fate Determination Neural Tube Formation Neural Tube Closure Heart Morphogenesis Signal Transduction Spermatid Development Regulation Of Mitotic Cell Cycle Pattern Specification Process Brain Development Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Xenobiotic Stimulus Response To Mechanical Stimulus Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Epidermal Cell Fate Specification Response To Chlorate Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Dorsal/ventral Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Prostate Gland Development Mammary Gland Development Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Response To Alkaloid Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Smooth Muscle Tissue Development Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Commissural Neuron Axon Guidance Stem Cell Proliferation Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Protein Localization To Plasma Membrane Liver Regeneration Negative Regulation Of Stem Cell Proliferation	Proteolysis Protein Autoprocessing Viral Translation Positive Regulation Of Viral Entry Into Host Cell Entry Receptor-mediated Virion Attachment To Host Cell
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO	Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion
Drugs			Bromhexine Camostat MM3122
Diseases		Holoprosencephaly (HPE) Basal cell carcinoma Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome	Prostate cancer
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adventurousness ( 30643258) Alanine aminotransferase levels ( 33547301) Anxiety ( 33859377) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 26733130) Bone mineral density (spine) ( 26733130) Brain morphology (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Dental caries (decayed, missing and filled teeth) ( 31533690) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 28869591 30598549) Height ( 25429064 28552196 31562340 18391952 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Macular thickness ( 30535121) Monobrow ( 27182965) Neurociticism ( 29500382) Nonsyndromic cleft lip with cleft palate ( 28232668) Offspring birth weight ( 31043758) Optic disc size ( 31809533) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		21 interacting genes: APPBP2 ATG101 ATM CCNB1 CD200R1 CD74 CD79A CDK1 CREB3 DHH FAM209A HIBADH HIPK2 IHH SHH SIGLEC12 SMO STOM TMPRSS2 TSPAN8 YAP1	60 interacting genes: ACE2 ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF UPK2 VAMP5 ZFPL1
Entrez ID		5727	7113
HPRD ID		03200	03637
Ensembl ID		ENSG00000185920	ENSG00000184012
Uniprot IDs		A0A0C4DGJ5 A0A1W5YLI7 Q13635	A0A7I2V474 O15393
PDB IDs		6DMB 6DMO 6DMY 6E1H 6N7G 6N7H 6N7K 6OEU 6OEV 6RMG 6RTW 6RTX 6RTY 6RVC 6RVD	7MEQ 7XYD 7Y0E 7Y0F 8HD8 8JHZ 8JI0 8S0L 8S0M 8S0N 8V04 8V1F 8VGT 8Y1D 8Y1E 8Y7X 8Y7Y 8Y87 8Y88 8Y89 8Y8A 8Y8B 8YOY 8YQQ 9IZN
Enriched GO Terms of Interacting Partners?		Patched Binding Cholesterol-protein Transferase Activity Protein Autoprocessing Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Self Proteolysis Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Somite Development Cyclin B1-CDK1 Complex Intein-mediated Protein Splicing Embryonic Heart Tube Morphogenesis Smooth Muscle Tissue Development Cell Fate Specification Developmental Growth Cell Development Regulation Of Organ Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Epithelial Tube Morphogenesis Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Heart Growth Positive Regulation Of Protein Import Into Nucleus Epithelial-mesenchymal Cell Signaling Cell Population Proliferation Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of T Cell Differentiation In Thymus Spinal Cord Dorsal/ventral Patterning Anterior/posterior Pattern Specification Positive Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Lymphocyte Activation Regulation Of Growth Ventricular Cardiac Muscle Cell Development Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Viral Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of T Cell Differentiation In Thymus	Membrane Endoplasmic Reticulum Membrane Protein Binding Positive Regulation Of Monocyte Chemotactic Protein-1 Production Alkenylglycerophosphocholine Hydrolase Activity Endoplasmic Reticulum Respiratory Burst After Phagocytosis Response To Bacterium Cytokine Activity Positive Regulation Of Chemokine Production CCR6 Chemokine Receptor Binding Killing By Host Of Symbiont Cells Chloride Channel Inhibitor Activity SNAP Receptor Activity Biological Process Involved In Interaction With Symbiont Identical Protein Binding Regulation Of Chemokine Production Respiratory Burst Involved In Defense Response
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