PTCH1 and CD79A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTCH1	CD79A
Description		patched 1	CD79a molecule
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Caveola Cilium Membrane Midbody Endocytic Vesicle Membrane Dendritic Growth Cone Axonal Growth Cone Apical Part Of Cell Postsynaptic Membrane Perinuclear Region Of Cytoplasm Ciliary Membrane	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Membrane B Cell Receptor Complex Membrane Raft IgM B Cell Receptor Complex
	Molecular Function	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein-containing Complex Binding Hedgehog Family Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Cell Fate Determination Neural Tube Formation Neural Tube Closure Heart Morphogenesis Signal Transduction Spermatid Development Regulation Of Mitotic Cell Cycle Pattern Specification Process Brain Development Negative Regulation Of Cell Population Proliferation Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Xenobiotic Stimulus Response To Mechanical Stimulus Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Epidermal Cell Fate Specification Response To Chlorate Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Dorsal/ventral Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Prostate Gland Development Mammary Gland Development Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Regulation Of Growth Negative Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Glucose Homeostasis Response To Alkaloid Keratinocyte Proliferation Positive Regulation Of Epidermal Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Smooth Muscle Tissue Development Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Commissural Neuron Axon Guidance Stem Cell Proliferation Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Protein Localization To Plasma Membrane Liver Regeneration Negative Regulation Of Stem Cell Proliferation	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway
Pathways		Class B/2 (Secretin family receptors) Hedgehog 'off' state Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Hedgehog 'on' state Activation of SMO	CD22 mediated BCR regulation Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Holoprosencephaly (HPE) Basal cell carcinoma Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Adventurousness ( 30643258) Alanine aminotransferase levels ( 33547301) Anxiety ( 33859377) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Bone mineral density (hip) ( 26733130) Bone mineral density (spine) ( 26733130) Brain morphology (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Dental caries (decayed, missing and filled teeth) ( 31533690) Feeling hurt ( 29500382) Feeling worry ( 29500382) Heel bone mineral density ( 28869591 30598549) Height ( 25429064 28552196 31562340 18391952 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung volume ( 34128465) Macular thickness ( 30535121) Monobrow ( 27182965) Neurociticism ( 29500382) Nonsyndromic cleft lip with cleft palate ( 28232668) Offspring birth weight ( 31043758) Optic disc size ( 31809533) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced pancreatitis in inflammatory bowel disease ( 29923122) Type 2 diabetes ( 32499647) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412)	Brain morphology (MOSTest) ( 32665545)
Interacting Genes		21 interacting genes: APPBP2 ATG101 ATM CCNB1 CD200R1 CD74 CD79A CDK1 CREB3 DHH FAM209A HIBADH HIPK2 IHH SHH SIGLEC12 SMO STOM TMPRSS2 TSPAN8 YAP1	192 interacting genes: ADGRE2 ADIPOQ AGTRAP ALG10 ALG10B ALG3 APOD AQP1 AQP3 ARLN ATP6V0C BCL2L2 BET1 BLK BLNK BRICD5 BTN2A2 C14orf180 C1GALT1 C2CD2L CATSPERH CCDC167 CD19 CD5 CD79B CD81 CDIPT CLDN1 CLN6 CMTM5 CMTM7 CNIH1 CNIH3 COL4A5 CTSA CTXN3 CYB561 CYB561A3 CYB561D2 CYB5B DEFB127 DOLK EDDM3B EMC6 EMP1 EMP3 FA2H FAM241B FANCA FATE1 FAXDC2 FCAR FDFT1 FFAR3 FKBP8 FUNDC2 FXYD3 FYN GALNT15 GIMAP1 GJB1 GPR42 HACD4 HCLS1 HMOX1 HMOX2 HTATIP2 IER3 IGHM INSIG2 ITGAM JAGN1 JCHAIN KCNS2 LAMB1 LCK LEPROTL1 LHFPL5 LNPEP LPAR3 LTC4S LYN MALL MARCHF2 MFF MFSD12 MFSD6 MGLL MMD2 MOSPD3 MS4A13 MYADM MYADML2 NAT8 NEU1 NINJ2 NIPAL3 NKG7 ORMDL1 ORMDL2 OTOP2 PEX16 PGAP2 PIGR PKMYT1 PLP2 PLPP6 PLPPR2 PNLIPRP1 PRAF2 PTCH1 PTPN6 REEP6 RHO RTP2 SACM1L SEC22B SERP1 SFTPC SLC13A4 SLC13A5 SLC16A12 SLC16A13 SLC30A2 SLC30A3 SLC35B1 SLC35B4 SLC38A1 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC46A3 SLC61A1 SLC66A2 SLC6A12 SLC7A1 SMCO4 SMIM3 STRIT1 STX12 STX3 STX8 SYK SYNJ2BP TECR THBD TM4SF19 TM4SF4 TMBIM6 TMEM107 TMEM11 TMEM128 TMEM140 TMEM147 TMEM14B TMEM176A TMEM187 TMEM19 TMEM218 TMEM222 TMEM229B TMEM239 TMEM243 TMEM254 TMEM42 TMEM86A TMEM86B TMEM97 TMPPE TNFRSF10C TRAM1L1 TRARG1 TSNARE1 TSPAN2 TSPO2 UBE2J1 UBIAD1 UNC93B1 UPK1B VAMP3 VAMP4 VAPA VAPB VTI1B WFDC2 WFS1 YIF1A YIPF4 YIPF6 ZDHHC15 ZDHHC22
Entrez ID		5727	973
HPRD ID		03200	00203
Ensembl ID		ENSG00000185920	ENSG00000105369
Uniprot IDs		A0A0C4DGJ5 A0A1W5YLI7 Q13635	P11912
PDB IDs		6DMB 6DMO 6DMY 6E1H 6N7G 6N7H 6N7K 6OEU 6OEV 6RMG 6RTW 6RTX 6RTY 6RVC 6RVD	1CV9 7WSO 7WSP 7XQ8 7XT6
Enriched GO Terms of Interacting Partners?		Patched Binding Cholesterol-protein Transferase Activity Protein Autoprocessing Smoothened Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Self Proteolysis Positive Regulation Of Organ Growth Regulation Of Cell Population Proliferation Somite Development Cyclin B1-CDK1 Complex Intein-mediated Protein Splicing Embryonic Heart Tube Morphogenesis Smooth Muscle Tissue Development Cell Fate Specification Developmental Growth Cell Development Regulation Of Organ Growth Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Smoothened Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Epithelial Tube Morphogenesis Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Heart Growth Positive Regulation Of Protein Import Into Nucleus Epithelial-mesenchymal Cell Signaling Cell Population Proliferation Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of T Cell Differentiation Regulation Of Protein Localization To Nucleus Positive Regulation Of T Cell Differentiation In Thymus Spinal Cord Dorsal/ventral Patterning Anterior/posterior Pattern Specification Positive Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Lymphocyte Activation Regulation Of Growth Ventricular Cardiac Muscle Cell Development Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Viral Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of T Cell Differentiation In Thymus	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding B Cell Receptor Signaling Pathway Plasma Membrane Transmembrane Transport Golgi Membrane SNAP Receptor Activity SNARE Complex Antigen Receptor-mediated Signaling Pathway Cellular Localization Membrane Docking Immune Response-regulating Cell Surface Receptor Signaling Pathway Membrane Fusion Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Organelle Localization By Membrane Tethering Vesicle Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Localization Within Membrane Protein Localization To Membrane T Cell Costimulation Chemical Homeostasis Membrane Organization Cholesterol Binding Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Monoatomic Cation Transmembrane Transporter Activity Intracellular Chemical Homeostasis Fc Receptor Signaling Pathway Metal Ion Transport Vesicle Fusion With Golgi Apparatus Vesicle-mediated Transport Endomembrane System Immune Response-activating Signaling Pathway Vesicle Docking Inorganic Cation Transmembrane Transport Membrane Lipid Metabolic Process Vacuolar Transmembrane Transport Phospholipase Binding Monoatomic Cation Transmembrane Transport Regulation Of Transport Regulation Of Immune System Process Establishment Of Localization In Cell Monoatomic Cation Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transport
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