MCPH1 and SKIC8

Number of citations of the paper that reports this interaction (PubMedID 29150431)
54

Data Source:
BioGRID (two hybrid)

		MCPH1	SKIC8
Description		microcephalin 1	SKI8 subunit of superkiller complex
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytoskeleton	Euchromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cdc73/Paf1 Complex Ski Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Regulation Of Gene Expression Cerebral Cortex Development Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance	Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Negative Regulation Of Myeloid Cell Differentiation Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome
Pathways		Condensation of Prophase Chromosomes	Formation of RNA Pol II elongation complex mRNA decay by 3' to 5' exoribonuclease RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		71 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CFTR CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DMC1 DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RAD51 RBM39 RSL24D1 RUVBL2 S100A16 SKIC8 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR73 WDR75 WNT10B ZMIZ2	11 interacting genes: ACVR1 BARD1 ERRFI1 EZH2 MCPH1 MSRB3 PRNP SMURF1 TCEA1 TGFBR1 YWHAQ
Entrez ID		79648	80349
HPRD ID		06174	15236
Ensembl ID		ENSG00000147316	ENSG00000140395
Uniprot IDs		A0A8I5KPV6 A0A8I5KR64 A0A8I5KR97 A0A8I5KV10 A0A8I5KW78 A0A8I5KZ89 Q8NEM0	H0YL19 Q9GZS3
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D	3OW8 6GMH 6TED 7OOP 7OPC 7OPD 7QDR 7QDS 7QDY 7QDZ 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9G8O 9G8Q 9G8R
Enriched GO Terms of Interacting Partners?		Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Stress Regulation Of DNA Repair Nucleic Acid Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Recombination Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Cellular Response To Gamma Radiation Protein Stabilization DNA Recombination Single-stranded DNA Binding Regulation Of Chromosome Organization Regulation Of Metabolic Process DNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Telomere Maintenance Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly DNA Strand Exchange Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination ATP Hydrolysis Activity Positive Regulation Of Macromolecule Metabolic Process Recombinational Repair Replicative Senescence Cytosol DNA Replication RNA Binding DNA Replication Origin Binding ATP Binding Double-strand Break Repair Regulation Of Macromolecule Biosynthetic Process DNA Repair Histone H2AXS139 Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Macromolecule Metabolic Process Single-stranded DNA Helicase Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Chromatin Remodeling	Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I SMAD Binding Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Activin Receptor Signaling Pathway I-SMAD Binding Regulation Of Epithelial To Mesenchymal Transition Pharyngeal System Development Regulation Of Metabolic Process Regulation Of Gene Expression Transforming Growth Factor Beta Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Mitotic Cell Cycle Phase Transition Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of DNA-templated Transcription Response To Stress Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Keratinocyte Differentiation Ventricular Septum Morphogenesis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of SMAD Protein Signal Transduction Growth Factor Binding Negative Regulation Of Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Endocardial Cushion Cell Fate Commitment Negative Regulation Of MRNA 3'-end Processing Hepatocyte Homeostasis Type 8 Metabotropic Glutamate Receptor Binding Engulfment Of Target By Autophagosome Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Cycle Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Epidermal Cell Differentiation Gland Development Cellular Response To Growth Factor Stimulus Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
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