MCPH1 and PPRC1

Number of citations of the paper that reports this interaction (PubMedID 29150431)
54

Data Source:
BioGRID (two hybrid)

		MCPH1	PPRC1
Description		microcephalin 1	PPARG related coactivator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytoskeleton	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Identical Protein Binding	Nucleic Acid Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Regulation Of Gene Expression Cerebral Cortex Development Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance	Positive Regulation Of Transcription By RNA Polymerase II Energy Homeostasis
Pathways		Condensation of Prophase Chromosomes	Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)	Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		71 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CFTR CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DMC1 DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RAD51 RBM39 RSL24D1 RUVBL2 S100A16 SKIC8 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR73 WDR75 WNT10B ZMIZ2	3 interacting genes: CLIC6 MCPH1 NRF1
Entrez ID		79648	23082
HPRD ID		06174	15173
Ensembl ID		ENSG00000147316	ENSG00000148840
Uniprot IDs		A0A8I5KPV6 A0A8I5KR64 A0A8I5KR97 A0A8I5KV10 A0A8I5KW78 A0A8I5KZ89 Q8NEM0	E7EVG6 Q5VV67
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D
Enriched GO Terms of Interacting Partners?		Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Stress Regulation Of DNA Repair Nucleic Acid Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Recombination Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Cellular Response To Gamma Radiation Protein Stabilization DNA Recombination Single-stranded DNA Binding Regulation Of Chromosome Organization Regulation Of Metabolic Process DNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Telomere Maintenance Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly DNA Strand Exchange Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination ATP Hydrolysis Activity Positive Regulation Of Macromolecule Metabolic Process Recombinational Repair Replicative Senescence Cytosol DNA Replication RNA Binding DNA Replication Origin Binding ATP Binding Double-strand Break Repair Regulation Of Macromolecule Biosynthetic Process DNA Repair Histone H2AXS139 Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Macromolecule Metabolic Process Single-stranded DNA Helicase Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Chromatin Remodeling	D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Third Ventricle Development
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