MCPH1 and ABCC2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MCPH1	ABCC2
Gene Name		microcephalin 1	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Apical Plasma Membrane Intercellular Canaliculus
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Mitotic Cell Cycle Cerebral Cortex Development	Transport Drug Transmembrane Transport Response To Oxidative Stress Metabolic Process Response To Heat Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport
Pathways		Mitotic Prophase Condensation of Prophase Chromosomes Cell Cycle, Mitotic M Phase	ABC-family proteins mediated transport
Drugs			Adenosine triphosphate Sulfinpyrazone
Diseases
GWAS		Cytomegalovirus antibody response ( 21993531) Epirubicin-induced leukopenia ( 21799462)
Protein-Protein Interactions		9 interactors: ABCC2 CHEK1 H2AFX KDM1A MCM2 PHF11 SMARCB1 SMARCC2 TADA2A	10 interactors: AZIN1 CANX MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 UBQLN1
Entrez ID		79648	1244
HPRD ID		06174	03065
Ensembl ID		ENSG00000147316	ENSG00000023839
Uniprot IDs		Q8NEM0	Q92887
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromosome Organization Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Modification Regulation Of Histone Modification Regulation Of Response To DNA Damage Stimulus Nucleosome Disassembly Nucleobase-containing Compound Metabolic Process Cell Cycle Process Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Remodeling Regulation Of Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of DNA Repair ATP-dependent Chromatin Remodeling Histone Modification Biosynthetic Process Regulation Of Primitive Erythrocyte Differentiation DNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stress Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Prostaglandin Transport Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Histone H3-T11 Phosphorylation Transcription, DNA-templated Nucleosome Assembly RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Chromatin Assembly DNA Repair Positive Regulation Of Cellular Metabolic Process DNA Damage Checkpoint Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Protein-DNA Complex Assembly Positive Regulation Of Gene Expression	Microvillus Assembly Microvillus Organization Protein Localization Renal Phosphate Ion Absorption Negative Regulation Of Interleukin-12 Biosynthetic Process Negative Regulation Of Guanylate Cyclase Activity Negative Regulation Of CGMP Biosynthetic Process Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Polyamine Transmembrane Transport Postsynaptic Density Assembly Guanylate Kinase-associated Protein Clustering Glutathione Transport Regulation Of Cytoskeleton Organization Negative Regulation Of Calcidiol 1-monooxygenase Activity Regulation Of Long Term Synaptic Depression Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Volume Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Chromosome Condensation Positive Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Monocarboxylic Acid Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Catalytic Activity Cellular Protein Localization Regulation Of Transmembrane Transporter Activity Cellular Localization Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Ion Transport Negative Regulation Of Vitamin D Biosynthetic Process Renal Sodium Ion Transport N-methyl-D-aspartate Receptor Clustering Vocal Learning Positive Regulation Of Synapse Structural Plasticity Negative Regulation Of Cytoskeleton Organization Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Transport Positive Regulation Of Ion Transport Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Positive Regulation Of Long-term Neuronal Synaptic Plasticity Phospholipase C-activating Dopamine Receptor Signaling Pathway Cellular Response To Nicotine Negative Regulation Of Catalytic Activity
Tagcloud ?		8p23 aberrantly advance alleviated aneuploidy bona break breaks brit1 centrosome chromatid comet convincing doi dsb fide heterozygosity joining karyotyping lymphomas meanwhile mefs metaphase multiplication onc online publication reconstituted	24c 24t 388g 521c abcc5 bjc bjcancer ces1 clarifying com diarrhoea doi glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www
Tagcloud (Difference) ?		8p23 aberrantly advance alleviated aneuploidy bona break breaks brit1 centrosome chromatid comet convincing dsb fide heterozygosity joining karyotyping lymphomas meanwhile mefs metaphase multiplication onc online publication reconstituted	24c 24t 388g 521c abcc5 bjc bjcancer ces1 clarifying com diarrhoea glucuronide hampered irinotecan journal metabolising oatp oatp1b3 personalising pfs pharmacogenetic rs2244613 rs562 slco1b1 sn ugt1a1 www
Tagcloud (Intersection) ?		doi