MCPH1 and RUVBL2

Number of citations of the paper that reports this interaction (PubMedID 29150431)
54

Data Source:
BioGRID (two hybrid)

		MCPH1	RUVBL2
Description		microcephalin 1	RuvB like AAA ATPase 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytoskeleton	Nucleosome Euchromatin Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Ciliary Basal Body Extracellular Exosome MLL1 Complex R2TP Complex Protein Folding Chaperone Complex Dynein Axonemal Particle RPAP3/R2TP/prefoldin-like Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Helicase Activity Protein Binding ATP Binding Beta-catenin Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Unfolded Protein Binding ATPase Binding Promoter-enhancer Loop Anchoring Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Regulation Of Gene Expression Cerebral Cortex Development Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance	Box C/D SnoRNP Assembly Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Folding DNA Damage Response Regulation Of Chromosome Organization Cellular Response To UV Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Protein Stabilization Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair
Pathways		Condensation of Prophase Chromosomes	Telomere Extension By Telomerase HATs acetylate histones
Drugs			Quercetin
Diseases		Primary microcephaly (MCPH)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		71 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CFTR CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DMC1 DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RAD51 RBM39 RSL24D1 RUVBL2 S100A16 SKIC8 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR73 WDR75 WNT10B ZMIZ2	34 interacting genes: AGR2 AKT1 APP APPL1 APPL2 ATF2 BCL3 CDKN2A CEBPA CTNNB1 DNAAF19 DNAJB4 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 NDRG1 OGT RUVBL1 STOM TAF9 TBP TERT TXNIP UBR5 YWHAQ
Entrez ID		79648	10856
HPRD ID		06174	16070
Ensembl ID		ENSG00000147316	ENSG00000183207
Uniprot IDs		A0A8I5KPV6 A0A8I5KR64 A0A8I5KR97 A0A8I5KV10 A0A8I5KW78 A0A8I5KZ89 Q8NEM0	B3KNL2 Q9Y230
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D	2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6K0R 6QI8 6QI9 7AHO 7OLE 7P6X 7ZI4 8QR1 8X15 8X19 8X1C 8XVG 8XVT 9C57 9C62 9EMA 9EMC
Enriched GO Terms of Interacting Partners?		Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Stress Regulation Of DNA Repair Nucleic Acid Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA Recombination Nucleus Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Cellular Response To Gamma Radiation Protein Stabilization DNA Recombination Single-stranded DNA Binding Regulation Of Chromosome Organization Regulation Of Metabolic Process DNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Telomere Maintenance Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly DNA Strand Exchange Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination ATP Hydrolysis Activity Positive Regulation Of Macromolecule Metabolic Process Recombinational Repair Replicative Senescence Cytosol DNA Replication RNA Binding DNA Replication Origin Binding ATP Binding Double-strand Break Repair Regulation Of Macromolecule Biosynthetic Process DNA Repair Histone H2AXS139 Kinase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Double-strand Break Repair Macromolecule Metabolic Process Single-stranded DNA Helicase Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Chromatin Remodeling	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein-containing Complex Negative Regulation Of Transcription By RNA Polymerase II Protein Localization To Organelle DNA-binding Transcription Factor Binding Positive Regulation Of Gene Expression Response To Stress Protein Import Into Nucleus Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Gene Expression Import Into Nucleus Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process P53 Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Developmental Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Metal Ion Nucleoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Nucleocytoplasmic Transport Nuclear Transport Regulation Of Cellular Localization Regulation Of Protein Localization To Nucleus Nucleus
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