INHBA and INHBC

Number of citations of the paper that reports this interaction (PMID 11134153)
10

Data Source:
HPRD (in vitro)

		INHBA	INHBC
Gene Name		inhibin, beta A	inhibin, beta C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Activin A Complex Inhibin A Complex	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein Heterodimerization Activity Type II Activin Receptor Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Growth Factor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ovarian Follicle Development Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Defense Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Endodermal Cell Differentiation Growth Negative Regulation Of Phosphorylation Odontogenesis Response To Drug Hemoglobin Biosynthetic Process Progesterone Secretion Regulation Of MAPK Cascade Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Palate Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cell Development SMAD Protein Signal Transduction
Pathways		Antagonism of Activin by Follistatin Peptide hormone metabolism Glycoprotein hormones Signaling by Activin Peptide hormone biosynthesis	Peptide hormone metabolism Glycoprotein hormones Peptide hormone biosynthesis
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462) Pit-and-Fissure caries ( 23470693) Prostate cancer (gene x gene interaction) ( 22219177)	Urate levels ( 20884846 23263486)
Protein-Protein Interactions		13 interactors: ACVR1 ACVR1B ACVR2A ACVR2B CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3	6 interactors: ACVR1 ACVR1B ACVR2A ACVR2B INHBA INHBB
Entrez ID		3624	3626
HPRD ID		00929	03136
Ensembl ID			ENSG00000175189
Uniprot IDs		A4D1W7 P08476	P55103
PDB IDs		1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Organ Development Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Development Of Primary Sexual Characteristics Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Sex Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Developmental Process System Development Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Signaling Multicellular Organismal Development Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of BMP Signaling Pathway Reproductive Process Gonad Development Regulation Of Phosphorus Metabolic Process Skeletal System Development Determination Of Left/right Symmetry Cell Surface Receptor Signaling Pathway Determination Of Bilateral Symmetry Regulation Of Cell Differentiation Development Of Primary Female Sexual Characteristics Tissue Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Single Organism Reproductive Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Bone Mineralization Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Biomineral Tissue Development Regulation Of Cellular Protein Metabolic Process Regulation Of Myeloid Cell Differentiation	Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Cellular Protein Metabolic Process Mesoderm Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Gastrulation Regulation Of Erythrocyte Differentiation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Development Of Primary Sexual Characteristics Developmental Process Involved In Reproduction Gastrulation With Mouth Forming Second Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Signal Transduction By Phosphorylation Sex Differentiation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Myeloid Cell Differentiation BMP Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Gonadotropin Secretion Positive Regulation Of Ossification Embryo Development Positive Regulation Of Cellular Metabolic Process Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Development Of Primary Female Sexual Characteristics Regulation Of Signal Transduction Reproductive Process Regulation Of Osteoblast Differentiation Organ Development Regulation Of Signaling
Tagcloud ?		acts bovine claudin dhh exogenous express inha inhbb inhibin kit1 manners meanwhile mediate medium melatonin mt1 mt2 occludin p21 pdgfa pg points reverse scs sertoli spermatogenesis supplementation testicular testis	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Difference) ?		acts bovine claudin dhh exogenous express inha inhbb inhibin kit1 manners meanwhile mediate medium melatonin mt1 mt2 occludin p21 pdgfa pg points reverse scs sertoli spermatogenesis supplementation testicular testis	aetiology ancestry college direction equivocal european europeans gckr genotyped gout hlf inconsistency loci maaori maf meeting obvious opposing pacific pdzk1 polynesian prkag2 replicated rheumatology sizes slc16a9 slc22a11 urate zealand
Tagcloud (Intersection) ?