INHBA and ACVR1B

Number of citations of the paper that reports this interaction (PMID 8397373)
53

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		INHBA	ACVR1B
Gene Name		inhibin, beta A	activin A receptor, type IB
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Activin A Complex Inhibin A Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Activin Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein Heterodimerization Activity Type II Activin Receptor Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type I Activin-activated Receptor Activity Growth Factor Binding Ubiquitin Protein Ligase Binding Inhibin Binding SMAD Binding Metal Ion Binding Activin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ovarian Follicle Development Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Defense Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Endodermal Cell Differentiation Growth Negative Regulation Of Phosphorylation Odontogenesis Response To Drug Hemoglobin Biosynthetic Process Progesterone Secretion Regulation Of MAPK Cascade Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Palate Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Hair Follicle Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Central Nervous System Development Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Cell Growth Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Development Of Primary Female Sexual Characteristics Protein Autophosphorylation Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		Antagonism of Activin by Follistatin Peptide hormone metabolism Glycoprotein hormones Signaling by Activin Peptide hormone biosynthesis	Signaling by Activin Regulation of signaling by NODAL Signaling by NODAL
Drugs			Adenosine triphosphate
Diseases
GWAS		Menarche (age at onset) ( 21102462) Pit-and-Fissure caries ( 23470693) Prostate cancer (gene x gene interaction) ( 22219177)	Urate levels ( 23263486)
Protein-Protein Interactions		13 interactors: ACVR1 ACVR1B ACVR2A ACVR2B CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3	20 interactors: ACVR2B BAG6 BAMBI BMPR2 FKBP1A IGSF1 INHBA INHBB INHBC NEDD4L OS9 PRKACB RXRA SMAD2 SMAD4 SMAD7 SNX1 SNX2 TDGF1 TGFBRAP1
Entrez ID		3624	91
HPRD ID		00929	03193
Ensembl ID			ENSG00000135503
Uniprot IDs		A4D1W7 P08476	P36896
PDB IDs		1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Organ Development Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Development Of Primary Sexual Characteristics Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Sex Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Developmental Process System Development Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Signaling Multicellular Organismal Development Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of BMP Signaling Pathway Reproductive Process Gonad Development Regulation Of Phosphorus Metabolic Process Skeletal System Development Determination Of Left/right Symmetry Cell Surface Receptor Signaling Pathway Determination Of Bilateral Symmetry Regulation Of Cell Differentiation Development Of Primary Female Sexual Characteristics Tissue Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Single Organism Reproductive Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Bone Mineralization Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Biomineral Tissue Development Regulation Of Cellular Protein Metabolic Process Regulation Of Myeloid Cell Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor SMAD Protein Signal Transduction Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Protein Phosphorylation Signal Transduction BMP Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Gastrulation Response To Organic Substance Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Signaling Cell Communication Positive Regulation Of Signal Transduction Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Tissue Morphogenesis Positive Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Mesoderm Development Regulation Of Signaling SMAD Protein Complex Assembly Heart Development Embryo Development Positive Regulation Of Phosphorylation Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		acts bovine claudin dhh exogenous express inha inhbb inhibin kit1 manners meanwhile mediate medium melatonin mt1 mt2 occludin p21 pdgfa pg points reverse scs sertoli spermatogenesis supplementation testicular testis	125b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Difference) ?		acts bovine claudin dhh exogenous express inha inhbb inhibin kit1 manners meanwhile mediate medium melatonin mt1 mt2 occludin p21 pdgfa pg points reverse scs sertoli spermatogenesis supplementation testicular testis	125b acvr2a arid3b bak1 bcl2l2 bear bim bmpr1b cadm1 cardio cardiology cmass e2f3 fgfr2 fgfr3 glut3 il6r jph2 men1 mirs onco orchestration raf1 sitr7 smoothened st7l twist1 wee1 wnt7a
Tagcloud (Intersection) ?