INHBA and FSTL3

Number of citations of the paper that reports this interaction (PMID 11459787)
22

Data Source:
HPRD (in vitro)

		INHBA	FSTL3
Gene Name		inhibin, beta A	follistatin-like 3 (secreted glycoprotein)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Activin A Complex Inhibin A Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Golgi Apparatus Secretory Granule Neuron Projection Terminus
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein Heterodimerization Activity Type II Activin Receptor Binding	Fibronectin Binding Protein Binding Activin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Ovarian Follicle Development Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Defense Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Cell-cell Signaling Nervous System Development Negative Regulation Of Cell Proliferation Male Gonad Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Endodermal Cell Differentiation Growth Negative Regulation Of Phosphorylation Odontogenesis Response To Drug Hemoglobin Biosynthetic Process Progesterone Secretion Regulation Of MAPK Cascade Negative Regulation Of Interferon-gamma Biosynthetic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Palate Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ossification Kidney Development Hematopoietic Progenitor Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spermatogenesis Male Gonad Development Positive Regulation Of Cell-cell Adhesion Lung Development Adrenal Gland Development Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Metal Ion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathways		Antagonism of Activin by Follistatin Peptide hormone metabolism Glycoprotein hormones Signaling by Activin Peptide hormone biosynthesis	Antagonism of Activin by Follistatin Signaling by Activin
Drugs
Diseases
GWAS		Menarche (age at onset) ( 21102462) Pit-and-Fissure caries ( 23470693) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		13 interactors: ACVR1 ACVR1B ACVR2A ACVR2B CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3	5 interactors: ADAM12 FN1 INHBA MSTN SMAD4
Entrez ID		3624	10272
HPRD ID		00929	05632
Ensembl ID			ENSG00000070404
Uniprot IDs		A4D1W7 P08476	O95633
PDB IDs		1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V	2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Organ Development Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Anatomical Structure Development Development Of Primary Sexual Characteristics Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Sex Differentiation Positive Regulation Of Activin Receptor Signaling Pathway Developmental Process System Development Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Developmental Process Involved In Reproduction Negative Regulation Of Signaling Multicellular Organismal Development Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of BMP Signaling Pathway Reproductive Process Gonad Development Regulation Of Phosphorus Metabolic Process Skeletal System Development Determination Of Left/right Symmetry Cell Surface Receptor Signaling Pathway Determination Of Bilateral Symmetry Regulation Of Cell Differentiation Development Of Primary Female Sexual Characteristics Tissue Development Cell Differentiation Positive Regulation Of Cellular Metabolic Process Single Organism Reproductive Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Bone Mineralization Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Biomineral Tissue Development Regulation Of Cellular Protein Metabolic Process Regulation Of Myeloid Cell Differentiation	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Endoderm Development Regulation Of Growth Gastrulation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Endodermal Cell Differentiation Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Endoderm Formation Cell Differentiation Growth Regulation Of Cell Differentiation Tissue Development Cell Development Ovulation Cycle Process Embryonic Morphogenesis Palate Development Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Myoblast Proliferation Negative Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Ovulation Cycle Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Differentiation Formation Of Primary Germ Layer Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mesoderm Development Anatomical Structure Development Progesterone Secretion Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Cell Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Response To Transforming Growth Factor Beta
Tagcloud ?		acts bovine claudin dhh exogenous express inha inhbb inhibin kit1 manners meanwhile mediate medium melatonin mt1 mt2 occludin p21 pdgfa pg points reverse scs sertoli spermatogenesis supplementation testicular testis
Tagcloud (Difference) ?		acts bovine claudin dhh exogenous express inha inhbb inhibin kit1 manners meanwhile mediate medium melatonin mt1 mt2 occludin p21 pdgfa pg points reverse scs sertoli spermatogenesis supplementation testicular testis
Tagcloud (Intersection) ?