RAB6B

Description		RAB6B, member RAS oncogene family
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Membrane Cytoplasmic Vesicle Ciliary Basal Body
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Neuron Projection Development Retrograde Transport, Endosome To Golgi Protein Localization To Golgi Membrane
Pathways		COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245)
Novel Interacting Genes		1 novel interacting genes: NPHP3
Interacting Genes		13 interacting genes: ACVR1 BICD2 BMPR1B COG6 ERC1 KIF20A LNX2 MEOX2 PMM1 RABGAP1 SH2B2 SMAD1 TGFBR1
Entrez ID		51560
HPRD ID		11474
Ensembl ID		ENSG00000154917
Uniprot IDs		Q9NRW1
PDB IDs		2E9S 2FE4 2FFQ
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type I SMAD Binding BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Activin Binding BMP Signaling Pathway Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Response To Growth Factor Pharyngeal System Development Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Binding Osteoblast Differentiation Regulation Of Osteoblast Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Cell Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Growth Factor Binding Endocardial Cushion Cell Fate Commitment Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Positive Regulation Of Ossification Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regionalization Dorsal/ventral Pattern Formation Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Embryonic Heart Tube Morphogenesis Bone Development Homomeric SMAD Protein Complex Phosphomannomutase Activity Vascular Endothelial Cell Proliferation
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