RAB6B and SH2B2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAB6B	SH2B2
Description		RAB6B, member RAS oncogene family	SH2B adaptor protein 2
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Membrane Cytoplasmic Vesicle Ciliary Basal Body	Stress Fiber Ruffle Cytoplasm Cytosol Actin Filament Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Neuron Projection Development Retrograde Transport, Endosome To Golgi Protein Localization To Golgi Membrane	B-1 B Cell Homeostasis Signal Transduction Insulin Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Metabolic Process Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Brown Fat Cell Differentiation
Pathways		COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245)	Hip circumference adjusted for BMI ( 34021172) Type 2 diabetes ( 31049640)
Interacting Genes		13 interacting genes: ACVR1 BICD2 BMPR1B COG6 ERC1 KIF20A LNX2 MEOX2 PMM1 RABGAP1 SH2B2 SMAD1 TGFBR1	42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13B EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417
Entrez ID		51560	10603
HPRD ID		11474	16097
Ensembl ID		ENSG00000154917	ENSG00000160999
Uniprot IDs		Q9NRW1	O14492
PDB IDs		2E9S 2FE4 2FFQ	1Q2H
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type I SMAD Binding BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Activin Binding BMP Signaling Pathway Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Response To Growth Factor Pharyngeal System Development Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Binding Osteoblast Differentiation Regulation Of Osteoblast Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Cell Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Growth Factor Binding Endocardial Cushion Cell Fate Commitment Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Positive Regulation Of Ossification Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regionalization Dorsal/ventral Pattern Formation Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Embryonic Heart Tube Morphogenesis Bone Development Homomeric SMAD Protein Complex Phosphomannomutase Activity Vascular Endothelial Cell Proliferation	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Phosphorylation Kinase Activity Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Modification Process Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Transferase Activity ATP Binding Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of MAPK Cascade Regulation Of Signal Transduction Nucleotide Binding Receptor Complex Cellular Response To Growth Factor Stimulus Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Response To Growth Factor Fc Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Signaling Regulation Of Cell Communication Regulation Of Gene Expression Epidermal Growth Factor Receptor Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Metabolic Process ERBB Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Component Organization Growth Hormone Receptor Signaling Pathway Via JAK-STAT Membrane Raft Protein Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Apoptotic Process
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