RAB6B and ERC1

Number of citations of the paper that reports this interaction (PubMedID 11929610)
0

Data Source:
HPRD (two hybrid, in vitro)

		RAB6B	ERC1
Description		RAB6B, member RAS oncogene family	ELKS/RAB6-interacting/CAST family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cytosol Endomembrane System Membrane Cytoplasmic Vesicle Ciliary Basal Body	Golgi Membrane Podosome Cytoplasm Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane IkappaB Kinase Complex Membrane Ciliary Basal Body Presynaptic Membrane Cell Projection Synapse Anchoring Junction Presynapse Presynaptic Active Zone Cytoplasmic Component
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding	Protein Binding PDZ Domain Binding Small GTPase Binding Cadherin Binding Structural Constituent Of Presynaptic Active Zone
	Biological Process	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Golgi Organization Protein Transport Vesicle-mediated Transport Neuron Projection Development Retrograde Transport, Endosome To Golgi Protein Localization To Golgi Membrane	Regulation Of DNA-templated Transcription I-kappaB Phosphorylation Protein Transport Retrograde Transport, Endosome To Golgi Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		COPI-independent Golgi-to-ER retrograde traffic Retrograde transport at the Trans-Golgi-Network TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Immune reponse to smallpox (secreted IL-1beta) ( 22610502) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245)	Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) ( 32595297) Body mass index ( 26426971) Femur bone mineral density x serum urate levels interaction ( 34046847) Forehead morphology ( 29921221) Height ( 29782485) Lumbar spine bone mineral density ( 22504420) Medial temporal lobe substructure volumes ( 32768867) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: ACVR1 BICD2 BMPR1B COG6 ERC1 KIF20A LNX2 MEOX2 PMM1 RABGAP1 SH2B2 SMAD1 TGFBR1	11 interacting genes: APP DNAJC5 DYRK1A ITSN2 PPFIA1 RAB6A RAB6B RIMS1 SRPK2 UBC YWHAG
Entrez ID		51560	23085
HPRD ID		11474	06181
Ensembl ID		ENSG00000154917	ENSG00000082805
Uniprot IDs		Q9NRW1	G8JLD3 Q8IUD2 X6RLX0 X6RM00
PDB IDs		2E9S 2FE4 2FFQ
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type I SMAD Binding BMP Receptor Activity Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Activin Binding BMP Signaling Pathway Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding Response To Growth Factor Pharyngeal System Development Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Binding Osteoblast Differentiation Regulation Of Osteoblast Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Cartilage Development Cell Fate Commitment Ventricular Septum Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Growth Factor Binding Endocardial Cushion Cell Fate Commitment Positive Regulation Of Biomineral Tissue Development Regulation Of Chondrocyte Differentiation Determination Of Stomach Left/right Asymmetry Determination Of Intestine Left/right Asymmetry Positive Regulation Of Ossification Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Regionalization Dorsal/ventral Pattern Formation Regulation Of SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Positive Regulation Of Determination Of Dorsal Identity Embryonic Heart Tube Morphogenesis Bone Development Homomeric SMAD Protein Complex Phosphomannomutase Activity Vascular Endothelial Cell Proliferation	Presynapse Endosome To Plasma Membrane Transport Vesicle Protein Localization To Golgi Membrane Vesicle-mediated Transport RAGE Receptor Binding Regulation Of Neuron Apoptotic Process Astrocyte Activation Positive Regulation Of Superoxide Anion Generation Myosin V Binding Positive Regulation Of Dendrite Extension Vesicle-mediated Transport In Synapse Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Regulation Of Superoxide Anion Generation Positive Regulation Of Monocyte Chemotaxis Protein Localization To Golgi Apparatus Regulation Of Superoxide Metabolic Process Microglial Cell Activation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Monocyte Chemotaxis Leukocyte Activation Involved In Inflammatory Response Synaptic Vesicle Exocytosis Intra-Golgi Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H3T45 Kinase Activity Peptidyl-cysteine Methylation Protein Methylation Positive Regulation Of Vitamin D 24-hydroxylase Activity Presynaptic Active Zone Positive Chemotaxis Regulation Of Cellular Component Organization Positive Regulation Of ERK1 And ERK2 Cascade Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Modulation Of Excitatory Postsynaptic Potential
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