FXYD1 and ATP1A1

Number of citations of the paper that reports this interaction (PMID 14597563)
28

Data Source:
HPRD (in vivo)

		FXYD1	ATP1A1
Gene Name		FXYD domain containing ion transport regulator 1	ATPase, Na+/K+ transporting, alpha 1 polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Chloride Channel Complex Sarcolemma	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane T-tubule Vesicle Sarcolemma Melanosome Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Binding	Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Phosphatase Activity Protein Kinase Binding Protein Domain Specific Binding Ankyrin Binding Potassium Ion Binding Sodium Ion Binding ADP Binding Phosphatidylinositol 3-kinase Binding Chaperone Binding Steroid Hormone Binding
	Biological Process	Chloride Transport Cellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Heart Contraction Ion Transmembrane Transport Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export From Cell Regulation Of Sodium Ion Transmembrane Transporter Activity	Regulation Of The Force Of Heart Contraction Regulation Of Sodium Ion Transport Cellular Sodium Ion Homeostasis Regulation Of Blood Pressure Potassium Ion Import Dephosphorylation Cellular Potassium Ion Homeostasis Negative Regulation Of Glucocorticoid Biosynthetic Process Ion Transmembrane Transport Sodium Ion Export From Cell Response To Drug Negative Regulation Of Heart Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Striated Muscle Contraction Transmembrane Transport Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Membrane Hyperpolarization Cellular Response To Mechanical Stimulus Cellular Response To Steroid Hormone Stimulus Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Response To Glycoside
Pathways		Ion transport by P-type ATPases Ion channel transport	Ion transport by P-type ATPases Ion channel transport
Drugs			Digoxin Acetyldigitoxin Hydroflumethiazide Ethacrynic acid Trichlormethiazide Deslanoside Ouabain Diazoxide Bretylium Bepridil Potassium Aluminium Magnesium Digitoxin Almitrine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATP1A1 ATP1B1 DMPK PAM PPAP2A PPP1CA PRKACA YWHAQ	14 interactors: A2M ADD1 CFL1 EGFR EZH2 FXYD1 FXYD2 FXYD7 HGS MAPK1 MAPK3 NDRG1 PRKCA TPT1
Entrez ID		5348	476
HPRD ID		03837	01662
Ensembl ID		ENSG00000266964	ENSG00000163399
Uniprot IDs		O00168	P05023
PDB IDs		2J1I 2JO1
Enriched GO Terms of Interacting Partners?		Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Regulation Of Heart Contraction Cardiac Conduction Sodium Ion Export From Cell Regulation Of Cardiac Muscle Contraction Sodium Ion Export Regulation Of Striated Muscle Contraction Cellular Potassium Ion Homeostasis Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cellular Metal Ion Homeostasis Cellular Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Cellular Cation Homeostasis Membrane Repolarization Cellular Ion Homeostasis Potassium Ion Homeostasis Metal Ion Homeostasis Regulation Of Muscle Contraction Cellular Chemical Homeostasis Ion Homeostasis Triglyceride Catabolic Process Relaxation Of Muscle Potassium Ion Import Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Sodium Ion Homeostasis Acylglycerol Catabolic Process Regulation Of The Force Of Heart Contraction Cellular Homeostasis Cardiac Muscle Cell Action Potential Cellular Calcium Ion Homeostasis Regulation Of Metabolic Process Membrane Organization Chemical Homeostasis Calcium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transport Heart Contraction Nuclear Envelope Organization Response To Abiotic Stimulus Endomembrane System Organization Striated Muscle Contraction Positive Regulation Of Dense Core Granule Biogenesis Action Potential Dephosphorylation Calcium-mediated Signaling Triglyceride Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Activation Platelet Activation Regulation Of MAP Kinase Activity Response To Epidermal Growth Factor Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Regulation Of Intracellular Signal Transduction Regulation Of Golgi Inheritance Positive Regulation Of Protein Phosphorylation Cell Differentiation Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Blood Coagulation Regulation Of Kinase Activity Hemostasis Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of MAPK Cascade Response To Fibroblast Growth Factor Positive Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of MAPKK Activity Neurotrophin Signaling Pathway Regulation Of Golgi Organization Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Body Fluid Levels Fc Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Chemotaxis Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stress Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport
Tagcloud ?		5k 5na alpha1 alpha1beta1 alpha2 alpha2beta1 alphabeta c12e8 detergent glycero histidine k0 kmatp oleoyl ouabain pastoris phophatidylserine phosphatidyl phospholipids pichia reconstituted somewhat sops stabilizes stearoyl suboptimal tm10 tm8 tm9	aldosterone betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption scnn1a scnn1b stepwise synergy transcriptomic
Tagcloud (Difference) ?		5k 5na alpha1 alpha1beta1 alpha2 alpha2beta1 alphabeta c12e8 detergent glycero histidine k0 kmatp oleoyl ouabain pastoris phophatidylserine phosphatidyl phospholipids pichia reconstituted somewhat sops stabilizes stearoyl suboptimal tm10 tm8 tm9	aldosterone betamethasone breaths compliance corticosteroid corticosteroids elastin enac enacalpha enacbeta epithelia fetuses gestation gr inflation infused infusions intravenously mineralocorticoid mr ovine pressures reabsorption scnn1a scnn1b stepwise synergy transcriptomic
Tagcloud (Intersection) ?