FXYD1 and PAM

Number of citations of the paper that reports this interaction (PubMedID 18052119)
0

Data Source:
HPRD (in vivo)

		FXYD1	PAM
Description		FXYD domain containing ion transport regulator 1	peptidylglycine alpha-amidating monooxygenase
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Apical Plasma Membrane T-tubule Sarcolemma	Extracellular Region Membrane Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Transmembrane Transporter Binding Ion Channel Regulator Activity	Catalytic Activity Monooxygenase Activity Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity L-ascorbic Acid Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Protein Glutathionylation Regulation Of Monoatomic Ion Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Sodium Ion Transmembrane Transport Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane	Peptide Amidation Peptide Metabolic Process Lipid Metabolic Process Response To Zinc Ion Cellular Response To Oxidative Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fatty Acid Primary Amide Biosynthetic Process
Pathways		Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs			Ascorbic acid N-Alpha-Acetyl-3,5-Diiodotyrosylglycine N-alpha-Acetyl-3,5-diiodotyrosyl-D-threonine
Diseases
GWAS			Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Daytime nap ( 33568662) Diastolic blood pressure ( 29208002) Early cardiac repolarization ( 31600170) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling worry ( 29500382) Insulinogenic index ( 23263489) Medication use (drugs used in diabetes) ( 31015401) Nicotine dependence symptom count ( 25555482) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Primary biliary cholangitis ( 26394269) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 29208002) Type 2 diabetes ( 30054458 30297969 29632382 29358691) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist-hip index ( 34021172)
Interacting Genes		9 interacting genes: ATP1A1 ATP1B1 DMPK PAM PLPP1 PPP1CA PRKACA SLC8A1 YWHAQ	9 interacting genes: CALM1 FXYD1 GLP1R KALRN POMC PRKCA RASSF9 TSC2 UHMK1
Entrez ID		5348	5066
HPRD ID		03837	01361
Ensembl ID		ENSG00000266964	ENSG00000145730
Uniprot IDs		O00168	A0A804HIQ0 A0A804HKM7 A0A804HKV8 A0A8C8KD64 O43832 P19021
PDB IDs		2JO1
Enriched GO Terms of Interacting Partners?		Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Cell Communication Involved In Cardiac Conduction Regulation Of Striated Muscle Contraction Regulation Of Muscle Contraction Regulation Of Monoatomic Ion Transport Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Sodium Ion Export Across Plasma Membrane Regulation Of Blood Circulation Regulation Of Muscle System Process Intracellular Potassium Ion Homeostasis Relaxation Of Muscle Intracellular Sodium Ion Homeostasis Regulation Of Metal Ion Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intracellular Monoatomic Cation Homeostasis Sodium Ion Homeostasis Potassium Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Calcium-mediated Signaling T-tubule Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Chemical Homeostasis Export Across Plasma Membrane Intracellular Signal Transduction Regulation Of System Process P-type Sodium:potassium-exchanging Transporter Activity Regulation Of Sodium Ion Transport Cellular Homeostasis Regulation Of Cardiac Muscle Contraction Regulation Of Monoatomic Ion Transmembrane Transport Extracellular Exosome Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Sodium:potassium-exchanging ATPase Complex Inorganic Cation Import Across Plasma Membrane Sarcolemma Sperm Flagellum Chemical Homeostasis Intracellular Signaling Cassette Sodium Ion Transmembrane Transport Regulation Of Transport Transmembrane Transporter Binding Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Membrane Potential Regulation Of Calcium Ion Transmembrane Transport Import Across Plasma Membrane Membrane Repolarization During Action Potential	Regulation Of System Process Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Heart Contraction Regulation Of Blood Circulation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Translational Initiation Response To Peptide Hormone Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of Protein Glutathionylation Positive Regulation Of Oxytocin Production Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Positive Regulation Of Dense Core Granule Biogenesis Protein Serine Kinase Activity Protein Phosphorylation Histone H3T6 Kinase Activity Phosphorylation Trans-Golgi Network Transport Vesicle Membrane Glucagon Receptor Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Translation Alphav-beta3 Integrin-PKCalpha Complex Protein Serine/threonine Kinase Activity Regulation Of Translational Initiation TSC1-TSC2 Complex Intracellular Signal Transduction Regulation Of Cell Cycle Cellular Pigmentation Type 1 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Type 3 Melanocortin Receptor Binding Protein Kinase C Signaling Transmembrane Transporter Binding Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Response To Psychosocial Stress Regulation Of Angiotensin-activated Signaling Pathway Protein Kinase Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Signal Transduction Vesicle-mediated Transport Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane
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