FXYD1 and PAM

Number of citations of the paper that reports this interaction (PMID 18052119)
37

Data Source:
HPRD (in vivo)

		FXYD1	PAM
Gene Name		FXYD domain containing ion transport regulator 1	peptidylglycine alpha-amidating monooxygenase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Sodium:potassium-exchanging ATPase Complex Chloride Channel Complex Sarcolemma	Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Chloride Channel Activity Sodium Channel Regulator Activity Ion Channel Binding	Peptidylglycine Monooxygenase Activity Peptidylamidoglycolate Lyase Activity Copper Ion Binding Protein Binding Zinc Ion Binding L-ascorbic Acid Binding
	Biological Process	Chloride Transport Cellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Heart Contraction Ion Transmembrane Transport Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Chloride Transmembrane Transport Positive Regulation Of Sodium Ion Export From Cell Regulation Of Sodium Ion Transmembrane Transporter Activity	Peptide Amidation Oxidation-reduction Process
Pathways		Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATP1A1 ATP1B1 DMPK PAM PPAP2A PPP1CA PRKACA YWHAQ	8 interactors: CALM1 FXYD1 KALRN POMC PRKCA RASSF9 TSC2 UHMK1
Entrez ID		5348	5066
HPRD ID		03837	01361
Ensembl ID		ENSG00000266964	ENSG00000145730
Uniprot IDs		O00168	P19021
PDB IDs		2J1I 2JO1
Enriched GO Terms of Interacting Partners?		Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Regulation Of Heart Contraction Cardiac Conduction Sodium Ion Export From Cell Regulation Of Cardiac Muscle Contraction Sodium Ion Export Regulation Of Striated Muscle Contraction Cellular Potassium Ion Homeostasis Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Cellular Metal Ion Homeostasis Cellular Sodium Ion Homeostasis Relaxation Of Cardiac Muscle Cellular Cation Homeostasis Membrane Repolarization Cellular Ion Homeostasis Potassium Ion Homeostasis Metal Ion Homeostasis Regulation Of Muscle Contraction Cellular Chemical Homeostasis Ion Homeostasis Triglyceride Catabolic Process Relaxation Of Muscle Potassium Ion Import Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Sodium Ion Homeostasis Acylglycerol Catabolic Process Regulation Of The Force Of Heart Contraction Cellular Homeostasis Cardiac Muscle Cell Action Potential Cellular Calcium Ion Homeostasis Regulation Of Metabolic Process Membrane Organization Chemical Homeostasis Calcium Ion Homeostasis Cardiac Muscle Contraction Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transport Heart Contraction Nuclear Envelope Organization Response To Abiotic Stimulus Endomembrane System Organization Striated Muscle Contraction Positive Regulation Of Dense Core Granule Biogenesis Action Potential Dephosphorylation Calcium-mediated Signaling Triglyceride Metabolic Process	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Heart Contraction Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Rhodopsin Mediated Signaling Pathway Activation Of Adenylate Cyclase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lyase Activity Response To External Stimulus Activation Of Phospholipase C Activity Negative Regulation Of Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cyclase Activity Positive Regulation Of Hydrolase Activity Regulation Of Cellular Localization Positive Regulation Of CAMP Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Phospholipase Activity Generation Of Precursor Metabolites And Energy Phototransduction, Visible Light Positive Regulation Of Ion Transmembrane Transport Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Phospholipase Activity Regulation Of CAMP Biosynthetic Process Positive Regulation Of Lipase Activity Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Regulation Of CAMP Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Detection Of Light Stimulus
Tagcloud ?		5k 5na alpha1 alpha1beta1 alpha2 alpha2beta1 alphabeta c12e8 detergent glycero histidine k0 kmatp oleoyl ouabain pastoris phophatidylserine phosphatidyl phospholipids pichia reconstituted somewhat sops stabilizes stearoyl suboptimal tm10 tm8 tm9	affirmative alcohol beneficial challenges college come cons consumption created debate drinking emerging explains face fall harrison held interesting meeting moderate news often physicians problems pros raises royal side won
Tagcloud (Difference) ?		5k 5na alpha1 alpha1beta1 alpha2 alpha2beta1 alphabeta c12e8 detergent glycero histidine k0 kmatp oleoyl ouabain pastoris phophatidylserine phosphatidyl phospholipids pichia reconstituted somewhat sops stabilizes stearoyl suboptimal tm10 tm8 tm9	affirmative alcohol beneficial challenges college come cons consumption created debate drinking emerging explains face fall harrison held interesting meeting moderate news often physicians problems pros raises royal side won
Tagcloud (Intersection) ?