UBE2Z and UBA1

Number of citations of the paper that reports this interaction (PubMedID 27425610)
60

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study)

		UBE2Z	UBA1
Description		ubiquitin conjugating enzyme E2 Z	ubiquitin like modifier activating enzyme 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Molecular Adaptor Activity Ubiquitin Conjugating Enzyme Activity	Nucleotide Binding RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Ubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Hexatantalum Dodecabromide Quercetin
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 29358691 30054458)
Interacting Genes		40 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 HUWE1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD	51 interacting genes: ABCF1 AZGP1P2 BUB3 CDK1 CEBPA CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A OGT PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2
Entrez ID		65264	7317
HPRD ID		08589	02440
Ensembl ID		ENSG00000159202	ENSG00000130985
Uniprot IDs		Q9H832	A0A024R1A3 P22314
PDB IDs		5A4P	4P22 6DC6 7PYV
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Metal Ion Binding Macromolecule Catabolic Process Protein Metabolic Process Zinc Ion Binding Transferase Activity Proteolysis Endoplasmic Reticulum Mannose Trimming Response To Stress Macromolecule Metabolic Process Protein Alpha-1,2-demannosylation Catabolic Process Proteasomal Protein Catabolic Process Protein Deglycosylation Endoplasmic Reticulum Quality Control Compartment Protein K63-linked Ubiquitination Protein Catabolic Process ERAD Pathway Protein K48-linked Ubiquitination I-SMAD Binding Cellular Response To Stress Protein Destabilization Ubiquitin Activating Enzyme Activity Response To Endoplasmic Reticulum Stress Regulation Of Protein Stability Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Ubiquitin Protein Ligase Binding Aggresome Assembly Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Complex Negative Regulation Of Mitochondrial Fusion Heteromeric SMAD Protein Complex Derlin-1 Retrotranslocation Complex Protein-containing Complex Binding Negative Regulation Of Type I Interferon Production Regulation Of Mitophagy Cytoplasm	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Protein Modification Process Protein K11-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process ATP Binding Transferase Activity Ubiquitin-dependent Protein Catabolic Process Nucleotide Binding Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Ubiquitin Protein Ligase Binding Protein Monoubiquitination Macromolecule Metabolic Process Catabolic Process Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K6-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Nucleoplasm ISG15 Transferase Activity HULC Complex DNA Damage Response ISG15-protein Conjugation Regulation Of Post-translational Protein Modification Free Ubiquitin Chain Polymerization Nucleus DNA Repair Positive Regulation Of Post-translational Protein Modification Protein K29-linked Ubiquitination Cellular Response To Stress Cell Cycle Phase Transition Ubiquitin Binding Regulation Of Protein Modification Process Protein K27-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination TORC1 Signaling DNA Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?