UBE2Z

Description		ubiquitin conjugating enzyme E2 Z
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Molecular Adaptor Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 29358691 30054458)
Interacting Genes		40 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 HUWE1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD
Entrez ID		65264
HPRD ID		08589
Ensembl ID		ENSG00000159202
Uniprot IDs		Q9H832
PDB IDs		5A4P
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Modification Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Metal Ion Binding Macromolecule Catabolic Process Protein Metabolic Process Zinc Ion Binding Transferase Activity Proteolysis Endoplasmic Reticulum Mannose Trimming Response To Stress Macromolecule Metabolic Process Protein Alpha-1,2-demannosylation Catabolic Process Proteasomal Protein Catabolic Process Protein Deglycosylation Endoplasmic Reticulum Quality Control Compartment Protein K63-linked Ubiquitination Protein Catabolic Process ERAD Pathway Protein K48-linked Ubiquitination I-SMAD Binding Cellular Response To Stress Protein Destabilization Ubiquitin Activating Enzyme Activity Response To Endoplasmic Reticulum Stress Regulation Of Protein Stability Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Transforming Growth Factor Beta Receptor Activity, Type I Ubiquitin Protein Ligase Binding Aggresome Assembly Positive Regulation Of Macromolecule Metabolic Process SMAD Protein Complex Negative Regulation Of Mitochondrial Fusion Heteromeric SMAD Protein Complex Derlin-1 Retrotranslocation Complex Protein-containing Complex Binding Negative Regulation Of Type I Interferon Production Regulation Of Mitophagy Cytoplasm
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