HTRA1 and CDYL

Number of citations of the paper that reports this interaction (PMID 15101818)
18

Data Source:
HPRD (two hybrid)

		HTRA1	CDYL
Gene Name		HtrA serine peptidase 1	chromodomain protein, Y-like
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol Extracellular Matrix Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	Serine-type Endopeptidase Activity Insulin-like Growth Factor Binding Serine-type Peptidase Activity	Transcription Corepressor Activity Histone Acetyltransferase Activity Protein Binding Methylated Histone Binding
	Biological Process	Regulation Of Cell Growth Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Dentinogenesis	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Spermatogenesis Histone Acetylation Negative Regulation Of Nucleic Acid-templated Transcription
Pathways
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Age-related macular degeneration (wet) ( 17053108)	Chronic obstructive pulmonary disease ( 21685187)
Protein-Protein Interactions		18 interactors: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM46A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 NOS3 PARD6B XIAP	5 interactors: HDAC1 HDAC2 HIST3H3 HTRA1 REST
Entrez ID		5654	9425
HPRD ID		03725	04803
Ensembl ID		ENSG00000166033	ENSG00000153046
Uniprot IDs		Q92743	Q9Y232
PDB IDs		2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ	2DNT 2GTR
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Presynaptic Membrane Organization Anatomical Structure Morphogenesis Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Response To Growth Factor Negative Regulation Of Cell Death Regulation Of Cell Motility Endochondral Ossification Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Presynaptic Membrane Organization Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Neuron Differentiation Cell Morphogenesis Involved In Differentiation Limb Morphogenesis Neurogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Cartilage Development Regulation Of Signaling Limb Development Collagen Fibril Organization Collagen Catabolic Process Artery Development Neuron Projection Development Regulation Of Cell Development Cellular Response To Organic Substance Cardiovascular System Development Blood Vessel Development Connective Tissue Development Collagen Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Differentiation Endochondral Bone Morphogenesis Endothelial Tube Morphogenesis Vasculature Development Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Skeletal System Development Multicellular Organismal Metabolic Process Neuron Development Regulation Of Apoptotic Process Axon Development	Histone H4 Deacetylation Histone Deacetylation Protein Deacetylation Odontogenesis Of Dentin-containing Tooth Fungiform Papilla Formation Fungiform Papilla Morphogenesis Positive Regulation Of Receptor Biosynthetic Process Odontogenesis Fungiform Papilla Development Negative Regulation By Host Of Viral Transcription Eyelid Development In Camera-type Eye Hair Follicle Placode Formation Tongue Morphogenesis Regulation Of Receptor Biosynthetic Process Negative Regulation Of Viral Transcription Histone H3 Deacetylation Chromosome Organization Interaction With Symbiont Tongue Development Histone H3-K9 Modification Negative Regulation Of Signaling Histone Modification Regulation Of Cell Proliferation Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Regulation Of Viral Transcription Circadian Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Viral Process Hair Follicle Development Hair Cycle Process Chromatin Modification Hair Cycle Negative Regulation Of Amniotic Stem Cell Differentiation Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Mesenchymal Stem Cell Differentiation Chromatin Organization Cardiocyte Differentiation Epidermal Cell Differentiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Regulation Of Viral Process Embryonic Limb Morphogenesis Circadian Rhythm Limb Morphogenesis Chromatin Remodeling Maintenance Of Chromatin Silencing Negative Regulation Of Neuron Differentiation Limb Development Organ Morphogenesis
Tagcloud ?		amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel	arborization bdnf chromodomain circuits complexity connections coordinately corepressor dendrite dendritic establishment ezh2 h3k27 interdependent knock knocking mechanistically morphogenesis neurodevelopment neurotrophic polycomb prc2 recruits repressive restrict shed throughput unleash unraveling
Tagcloud (Difference) ?		amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek subcortical unravel	arborization bdnf chromodomain circuits complexity connections coordinately corepressor dendrite dendritic establishment ezh2 h3k27 interdependent knock knocking mechanistically morphogenesis neurodevelopment neurotrophic polycomb prc2 recruits repressive restrict throughput unleash unraveling
Tagcloud (Intersection) ?		shed