HTRA1 and CDYL

Number of citations of the paper that reports this interaction (PubMedID 15101818)
30

Data Source:
HPRD (two hybrid)

		HTRA1	CDYL
Description		HtrA serine peptidase 1	chromodomain Y like
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Matrix Extracellular Exosome	Nucleus Chromosome Cytoplasm Nuclear Speck
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Growth Factor Binding Identical Protein Binding Molecular Function Activator Activity	Chromatin Binding Transcription Corepressor Activity Protein Binding Lyase Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Crotonyl-CoA Hydratase Activity
	Biological Process	Placenta Development Proteolysis Programmed Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Apoptotic Process Chorionic Trophoblast Cell Differentiation	Spermatogenesis Spermatid Development Cell Differentiation Negative Regulation Of DNA-templated Transcription Random Inactivation Of X Chromosome Negative Regulation Of Peptidyl-lysine Crotonylation
Pathways		Degradation of the extracellular matrix
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 20861866 21665990 22694956 32741009 23326517 23455636 23536807) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 33020668 29212778) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30804560 30061609) Migraine ( 27322543) Myocardial infarction ( 33532862) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Systolic blood pressure ( 30578418 30224653) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Body mass index ( 28552196) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Red cell distribution width ( 32888494) Response to ketogenic dietary therapies in epilepsy ( 30009487) Weight ( 28552196)
Interacting Genes		22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP	9 interacting genes: FXR1 H3-4 H3C1 HDAC1 HDAC2 HTRA1 LIG1 REST TTC9C
Entrez ID		5654	9425
HPRD ID		03725	04803
Ensembl ID		ENSG00000166033	ENSG00000153046
Uniprot IDs		Q92743	Q9Y232
PDB IDs		2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ 6Z0E 6Z0X 6Z0Y 7SJN 7SJO 7SJP 8SDM 8SDP 8SE7 8SE8	2DNT 2GTR 7N27
Enriched GO Terms of Interacting Partners?		Cartilage Development Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Chondrocyte Differentiation Endoplasmic Reticulum Lumen Endochondral Ossification Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Ossification Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Cell Motility Identical Protein Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Locomotion Blood Vessel Development Anatomical Structure Morphogenesis Lipoprotein Particle Binding Regulation Of Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Communication Negative Regulation Of Apoptotic Process Regulation Of Signaling Collagen Fibril Organization Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Cell-cell Signaling Negative Regulation Of Long-term Synaptic Potentiation Regulation Of SMAD Protein Signal Transduction Embryonic Skeletal Joint Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Extracellular Region Signaling Collagen Trimer Cell Communication Positive Regulation Of Developmental Process Extracellular Matrix Pulmonary Valve Morphogenesis Negative Regulation Of Platelet Activation Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric Oxide Mediated Signal Transduction Cartilage Development Involved In Endochondral Bone Morphogenesis Lung Development Regulation Of Programmed Cell Death Limb Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of BMP Signaling Pathway	Protein Decrotonylase Activity Histone Decrotonylase Activity Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of Stem Cell Population Maintenance Hair Follicle Placode Formation Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation Chromatin Remodeling Histone Deacetylase Activity, Hydrolytic Mechanism Host-mediated Suppression Of Viral Transcription Eyelid Development In Camera-type Eye Protein Lysine Deacetylase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neurogenesis Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Host-mediated Suppression Of Viral Proces NuRD Complex Chromatin Organization Histone Deacetylase Activity Regulation Of Nervous System Development RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of Oligodendrocyte Differentiation Sin3-type Complex Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Host-mediated Perturbation Of Viral Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding NF-kappaB Binding Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Neurogenesis Nucleosomal DNA Binding Positive Regulation Of Glial Cell Differentiation Regulation Of Oligodendrocyte Differentiation Histone Deacetylase Complex Regulation Of Cell Fate Commitment Positive Regulation Of Nervous System Development Heterochromatin Epigenetic Regulation Of Gene Expression Embryonic Digit Morphogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Gliogenesis Transcription Repressor Complex Positive Regulation Of Male Mating Behavior Okazaki Fragment Processing Involved In Mitotic DNA Replication Negative Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Amniotic Stem Cell Differentiation
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