HTRA1 and GDF5

Number of citations of the paper that reports this interaction (PubMedID 14973287)
0

Data Source:
HPRD (in vitro)

		HTRA1	GDF5
Description		HtrA serine peptidase 1	growth differentiation factor 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Growth Factor Binding Identical Protein Binding Molecular Function Activator Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity BMP Binding Identical Protein Binding
	Biological Process	Placenta Development Proteolysis Programmed Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Apoptotic Process Chorionic Trophoblast Cell Differentiation	Chondrocyte Differentiation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Ossification Involved In Bone Remodeling Positive Regulation Of Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Positive Regulation Of SMAD Protein Signal Transduction Chondroblast Differentiation Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Apoptotic Process Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Degradation of the extracellular matrix	Molecules associated with elastic fibres
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome Fibular hypoplasia and complex brachydactyly; DuPan syndrome Grebe dysplasia; Acromesomelic dysplasia Hunter-Thompson type Brachydactyly, including: Brachydactyly type C; Angel shaped phalangoepiphyseal dysplasia (ASPED)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 20861866 21665990 22694956 32741009 23326517 23455636 23536807) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 33020668 29212778) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30804560 30061609) Migraine ( 27322543) Myocardial infarction ( 33532862) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Systolic blood pressure ( 30578418 30224653) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Femoral neck size ( 31053729) Height ( 18391951 34270706 33713608 31562340 28552196 18391950 18391952 20189936 20881960 23563607 25282103 25429064) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Infant length ( 25281659) Intertrochanteric region size ( 31053729) Joint mobility (Beighton score) ( 27182965) Knee osteoarthritis ( 30374069 30664745) Knee pain ( 31482140) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Refractive error ( 32231278) Spine bone size ( 31053729) Trochanter size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP	8 interacting genes: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1
Entrez ID		5654	8200
HPRD ID		03725	03092
Ensembl ID		ENSG00000166033	ENSG00000125965
Uniprot IDs		Q92743	F1T0J1 P43026
PDB IDs		2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ 6Z0E 6Z0X 6Z0Y 7SJN 7SJO 7SJP 8SDM 8SDP 8SE7 8SE8	1WAQ 2BHK 3EVS 3QB4 5HK5 6Z3G 6Z3H 6Z3J 6Z3L 6Z3M 7ZJF 8BWL 8BWM 8BWN 8E3G
Enriched GO Terms of Interacting Partners?		Cartilage Development Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Chondrocyte Differentiation Endoplasmic Reticulum Lumen Endochondral Ossification Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Ossification Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Cell Motility Identical Protein Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Locomotion Blood Vessel Development Anatomical Structure Morphogenesis Lipoprotein Particle Binding Regulation Of Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Communication Negative Regulation Of Apoptotic Process Regulation Of Signaling Collagen Fibril Organization Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Cell-cell Signaling Negative Regulation Of Long-term Synaptic Potentiation Regulation Of SMAD Protein Signal Transduction Embryonic Skeletal Joint Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Extracellular Region Signaling Collagen Trimer Cell Communication Positive Regulation Of Developmental Process Extracellular Matrix Pulmonary Valve Morphogenesis Negative Regulation Of Platelet Activation Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric Oxide Mediated Signal Transduction Cartilage Development Involved In Endochondral Bone Morphogenesis Lung Development Regulation Of Programmed Cell Death Limb Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of BMP Signaling Pathway	Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Receptor Activity Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Binding Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II BMP Binding Regionalization Cellular Response To Growth Factor Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Response To Growth Factor Osteoblast Differentiation Animal Organ Development Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Mitral Valve Morphogenesis Pattern Specification Process Protein Serine/threonine Kinase Activity Mesoderm Development Receptor Complex Activin Binding Protein Kinase Activity Regulation Of SMAD Protein Signal Transduction Gastrulation With Mouth Forming Second Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Atrioventricular Valve Morphogenesis Cell Differentiation Regulation Of Activin Receptor Signaling Pathway Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Anterior/posterior Pattern Specification Cellular Developmental Process Ventricular Septum Morphogenesis Regulation Of Signal Transduction Mesoderm Formation Gastrulation
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