HTRA1 and COL1A1

Number of citations of the paper that reports this interaction (PMID 15101818)
18

Data Source:
HPRD (two hybrid)

		HTRA1	COL1A1
Gene Name		HtrA serine peptidase 1	collagen, type I, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Secretory Granule Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Insulin-like Growth Factor Binding Serine-type Peptidase Activity	Extracellular Matrix Structural Constituent Protein Binding Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Regulation Of Cell Growth Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Dentinogenesis	Skeletal System Development Blood Vessel Development Osteoblast Differentiation Intramembranous Ossification Endochondral Ossification Receptor-mediated Endocytosis Blood Coagulation Visual Perception Sensory Perception Of Sound Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell-substrate Adhesion Protein Transport Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Corticosteroid Response To Estradiol Collagen Biosynthetic Process Protein Localization To Nucleus Tooth Mineralization Response To Drug Response To Hydrogen Peroxide Response To Peptide Hormone Skin Morphogenesis Cellular Response To Fibroblast Growth Factor Stimulus Tooth Eruption Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development Leukocyte Migration Response To CAMP Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Cartilage Development Involved In Endochondral Bone Morphogenesis Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Cellular Response To Mechanical Stimulus Cellular Response To Retinoic Acid Cellular Response To Vitamin E Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Fluoride
Pathways			Platelet Adhesion to exposed collagen Collagen formation Collagen degradation Anchoring fibril formation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Syndecan interactions Crosslinking of collagen fibrils ECM proteoglycans GPVI-mediated activation cascade Integrin cell surface interactions Collagen biosynthesis and modifying enzymes Platelet activation, signaling and aggregation Scavenging by Class A Receptors
Drugs			Collagenase
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Age-related macular degeneration (wet) ( 17053108)	Breast cancer ( 17903305) Response to taxane treatment (docetaxel) ( 23006423)
Protein-Protein Interactions		18 interactors: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM46A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 NOS3 PARD6B XIAP	37 interactors: ACHE ATP13A2 BARD1 BGN BMP1 BRCA1 CAPN1 CD36 CD44 CD93 COL7A1 DCN DDR2 FGF7 FN1 HTRA1 IGFBP3 ITGA2 ITGA5 MAG MATN2 MMP2 MMP9 NID1 NID2 P4HB PAK1 PDGFA PDGFB PKD1 PRELP SPARC TGFBI THBS1 TMPRSS6 TXN VWF
Entrez ID		5654	1277
HPRD ID		03725	00362
Ensembl ID		ENSG00000166033	ENSG00000108821
Uniprot IDs		Q92743	P02452
PDB IDs		2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ	1Q7D 2LLP 3EJH 3GXE
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Presynaptic Membrane Organization Anatomical Structure Morphogenesis Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Response To Growth Factor Negative Regulation Of Cell Death Regulation Of Cell Motility Endochondral Ossification Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Presynaptic Membrane Organization Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Neuron Differentiation Cell Morphogenesis Involved In Differentiation Limb Morphogenesis Neurogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Cartilage Development Regulation Of Signaling Limb Development Collagen Fibril Organization Collagen Catabolic Process Artery Development Neuron Projection Development Regulation Of Cell Development Cellular Response To Organic Substance Cardiovascular System Development Blood Vessel Development Connective Tissue Development Collagen Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Differentiation Endochondral Bone Morphogenesis Endothelial Tube Morphogenesis Vasculature Development Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Skeletal System Development Multicellular Organismal Metabolic Process Neuron Development Regulation Of Apoptotic Process Axon Development	Extracellular Matrix Organization Extracellular Structure Organization Response To Wounding Extracellular Matrix Disassembly Wound Healing Multicellular Organismal Development Cell Adhesion Anatomical Structure Development Tissue Development Platelet Degranulation Developmental Process System Development Blood Coagulation Hemostasis Anatomical Structure Morphogenesis Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Metabolic Process Regulation Of Locomotion Regulation Of Cellular Amino Acid Metabolic Process Response To Stress Regulation Of Cellular Component Movement Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Body Fluid Levels Regulation Of Cell Migration Cell-substrate Adhesion Regulation Of Epithelial Cell Migration Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Phosphorylation Endodermal Cell Differentiation Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Skeletal System Development Regulation Of Cellular Protein Metabolic Process Organ Development Blood Vessel Morphogenesis Regulation Of Phosphorus Metabolic Process Platelet Activation Organ Morphogenesis Locomotion Endoderm Formation Angiogenesis Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Exocytosis
Tagcloud ?		amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Difference) ?		amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel	archive bcl6 cancerous cebpb checked cufflinks david deg degs downloaded exph5 fastqc hg19 msx2 noiseq paracancerous ppp2r2c read samtools sox4 srp009386 tophat totally transfa trp53 uniquely v1 vcftools
Tagcloud (Intersection) ?