HTRA1 and COL3A1

Number of citations of the paper that reports this interaction (PubMedID 15101818)
30

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		HTRA1	COL3A1
Description		HtrA serine peptidase 1	collagen type III alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Matrix Extracellular Exosome	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type III Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Growth Factor Binding Identical Protein Binding Molecular Function Activator Activity	Protease Binding Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Placenta Development Proteolysis Programmed Cell Death Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Apoptotic Process Chorionic Trophoblast Cell Differentiation	Blood Vessel Development In Utero Embryonic Development Neuron Migration Tissue Homeostasis Chondrocyte Differentiation Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Heart Development Response To Radiation Gene Expression Peptide Cross-linking Layer Formation In Cerebral Cortex Cerebral Cortex Development Platelet Activation Extracellular Matrix Organization Collagen Fibril Organization Lung Development Transforming Growth Factor Beta1 Production Response To Cytokine Positive Regulation Of Rho Protein Signal Transduction Multicellular Organism Growth Aorta Development Limb Joint Morphogenesis Wound Healing Skin Development Fibroblast Proliferation Elastic Fiber Assembly Animal Organ Development Digestive Tract Development System Development Negative Regulation Of Immune Response Cartilage Development Endochondral Bone Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Cellular Response To Amino Acid Stimulus Basement Membrane Organization Supramolecular Fiber Organization Response To Angiotensin Negative Regulation Of Neuron Migration
Pathways		Degradation of the extracellular matrix	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs			Collagenase clostridium histolyticum
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 20861866 21665990 22694956 32741009 23326517 23455636 23536807) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (geographic atrophy) ( 22705344) Age-related macular degeneration (MTAG) ( 32277175) Age-related macular degeneration (wet) ( 17053108) Coronary artery disease ( 33020668 29212778) Disease progression in age-related macular degeneration ( 29346644) Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644) Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644) Diverticular disease ( 30177863) Early age-related macular degeneration ( 32843070) Exudative age-related macular degeneration ( 25629512) Laterality in neovascular age-related macular degeneration ( 28775256) Lung function (FEV1/FVC) ( 30804560 30061609) Migraine ( 27322543) Myocardial infarction ( 33532862) Neovascular age-related macular degeneration ( 28703135) Refractive error ( 32231278) Systolic blood pressure ( 30578418 30224653) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness x smoking interaction ( 32117412) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Parkinson disease and lewy body pathology ( 25663231) Platelet distribution width ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		22 interacting genes: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM107A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 LTBP1 MAPT NOS3 PARD6B RPS6KA1 TENT5A XIAP	14 interacting genes: AP2B1 CAPN1 DDR1 DDR2 FGF7 HTRA1 MAG MYOC PCOLCE PDGFA PDGFB SPARC THBS1 VWF
Entrez ID		5654	1281
HPRD ID		03725	00365
Ensembl ID		ENSG00000166033	ENSG00000168542
Uniprot IDs		Q92743	A0AAG2UVC5 P02461
PDB IDs		2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ 6Z0E 6Z0X 6Z0Y 7SJN 7SJO 7SJP 8SDM 8SDP 8SE7 8SE8	2V53 3DMW 4AE2 4AEJ 4AK3 4GYX 6FZV 6FZW 7WWR 7WWS 7XAN
Enriched GO Terms of Interacting Partners?		Cartilage Development Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Chondrocyte Differentiation Endoplasmic Reticulum Lumen Endochondral Ossification Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Regulation Of Cell Migration Ossification Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Cell Motility Identical Protein Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Locomotion Blood Vessel Development Anatomical Structure Morphogenesis Lipoprotein Particle Binding Regulation Of Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Communication Negative Regulation Of Apoptotic Process Regulation Of Signaling Collagen Fibril Organization Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Cell-cell Signaling Negative Regulation Of Long-term Synaptic Potentiation Regulation Of SMAD Protein Signal Transduction Embryonic Skeletal Joint Morphogenesis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Extracellular Region Signaling Collagen Trimer Cell Communication Positive Regulation Of Developmental Process Extracellular Matrix Pulmonary Valve Morphogenesis Negative Regulation Of Platelet Activation Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Nitric Oxide Mediated Signal Transduction Cartilage Development Involved In Endochondral Bone Morphogenesis Lung Development Regulation Of Programmed Cell Death Limb Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of BMP Signaling Pathway	Collagen Binding Platelet Alpha Granule Lumen Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Space Extracellular Region Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Protein Tyrosine Kinase Collagen Receptor Activity Response To Wounding Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Platelet Alpha Granule Extracellular Matrix Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Extracellular Matrix Structural Constituent Regulation Of Body Fluid Levels Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process Regulation Of Wound Healing Regulation Of Cellular Component Organization Negative Regulation Of Phospholipid Biosynthetic Process Regulation Of Endothelial Cell Proliferation Animal Organ Development Regulation Of Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Cell Motility Regulation Of MAPK Cascade Regulation Of Response To Wounding Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Signal Transduction Regulation Of Branching Involved In Salivary Gland Morphogenesis Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Phosphorylation Regulation Of Blood Coagulation Regulation Of Cell-substrate Adhesion Regulation Of Hemostasis Regulation Of Smooth Muscle Cell Migration Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Signal Transduction
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