E2F3 and CCNF

Number of citations: 0 (PubMedID 36607545)
Data Source: BioGRID (affinity chromatography technology, two hybrid)

		E2F3	CCNF
Name		E2F transcription factor 3	cyclin F
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol RNA Polymerase II Transcription Regulator Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytosol Cytoskeleton SCF Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding Anaphase-promoting Complex Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	G1/S Transition Of Mitotic Cell Cycle Re-entry Into Mitotic Cell Cycle Placenta Development Negative Regulation Of Centrosome Duplication Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Regulation Of Cell Cycle
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence G2 Phase Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Adult body size ( 32376654 ) Alanine aminotransferase levels ( 33547301 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Hip index ( 34021172 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Metabolite levels ( 23823483 ) Molybdenum levels ( 26025379 ) Obesity-related traits ( 23251661 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Walking pace ( 33128006 )	Height ( 28552196 ) Triglyceride levels ( 32203549 )
Interacting Genes		26 interacting genes: ATAD2 CCNA2 CCNF CDK3 DNMT3L FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RCAN1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 UCHL5 WNK1 YY1	10 interacting genes: AKT1 CCNB1 E2F1 E2F2 E2F3 FZR1 MYBL2 RBPJ SCYL1 SQSTM1
Entrez ID		1871	899
HPRD ID		02693	02574
Ensembl ID		ENSG00000112242	ENSG00000162063
Uniprot IDs		O00716	P41002 Q59HD0
PDB IDs		Not available	9CB3
GO Terms Enriched among Interactors		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Chromatin Remodeling G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Organization Rb-E2F Complex Transcription Regulator Complex Cyclin-dependent Protein Kinase Holoenzyme Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Mitotic Cell Cycle Phase Transition Anaphase-promoting Complex Binding Cell Cycle Phase Transition DNA Binding DNA-binding Transcription Factor Binding Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Ino80 Complex Regulation Of DNA Strand Elongation Response To Hormone Transcription Factor Binding Negative Regulation Of Calcium-mediated Signaling Regulation Of Chromosome Organization	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Lens Fiber Cell Apoptotic Process Positive Regulation Of Organ Growth Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Positive Regulation Of Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm Regulation Of Organ Growth Anoikis Regulation Of Mitotic Cell Cycle Phase Transition Protein Import Into Nucleus Import Into Nucleus Nucleus Regulation Of Generation Of Precursor Metabolites And Energy RNA Polymerase II Transcription Regulator Complex Macromolecule Biosynthetic Process Labyrinthine Layer Blood Vessel Development Cellular Response To Decreased Oxygen Levels Nucleobase-containing Compound Biosynthetic Process Regulation Of RNA Metabolic Process Anaphase-promoting Complex-dependent Catabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Cell Cycle Phase Transition DNA-binding Transcription Activator Activity Cellular Response To Oxygen Levels Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein Kinase Binding Positive Regulation Of Developmental Growth Sequence-specific DNA Binding Regulation Of Cell Population Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Placenta Blood Vessel Development Positive Regulation Of Macromolecule Biosynthetic Process Protein Dimerization Activity Regulation Of Protein Ubiquitination