E2F3 and TFDP2

Number of citations of the paper that reports this interaction (PMID 7739537)
49

Data Source:
HPRD (two hybrid, in vivo)

		E2F3	TFDP2
Gene Name		E2F transcription factor 3	transcription factor Dp-2 (E2F dimerization partner 2)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle	Nucleoplasm Transcription Factor Complex
	Molecular Function	Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transcription Factor Binding Protein Domain Specific Binding
	Biological Process	Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated	Mitotic Cell Cycle Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase Cellular Senescence M/G1 Transition Regulation of DNA replication CDC6 association with the ORC:origin complex Oncogene Induced Senescence Cell Cycle, Mitotic Assembly of the pre-replicative complex Cyclin D associated events in G1 Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence G2 Phase Pre-NOTCH Expression and Processing Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Mitotic G1-G1/S phases	Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Pre-NOTCH Transcription and Translation Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Chronic kidney disease ( 20383146)
Protein-Protein Interactions		23 interactors: ATAD2 CCNA2 CDK3 CREBBP FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 WNK1 YY1	6 interactors: E2F1 E2F2 E2F3 E2F4 E2F6 YWHAE
Entrez ID		1871	7029
HPRD ID		02693	03696
Ensembl ID		ENSG00000112242	ENSG00000114126
Uniprot IDs		O00716 Q24JQ3	Q14188
PDB IDs			1CF7
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Positive Regulation Of Metabolic Process Mitotic Nuclear Division Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Cell Cycle DNA-templated Transcription, Initiation Mitotic Cell Cycle Process Regulation Of Cellular Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Cell Cycle Process Cell Division Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Enucleate Erythrocyte Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Transferase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle	Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Lens Fiber Cell Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway Mitotic Cell Cycle Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Transcription, DNA-templated Cell Cycle Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator RNA Biosynthetic Process Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization RNA Metabolic Process Signal Transduction By P53 Class Mediator Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone Notch Signaling Pathway Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Apoptotic Process Nucleobase-containing Compound Metabolic Process Programmed Cell Death Negative Regulation Of Protein Dephosphorylation Multi-ciliated Epithelial Cell Differentiation Positive Regulation Of Intracellular Transport Cell Death Death Anoikis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression
Tagcloud ?		34a arrest carcinogenic chemokine concern concerned creates ct cytotoxicity doses frequent greatly involves ionizing killer mammographies medical micro mir mirna overexposure pathways patterns presentation radiation ray scans successfully workers	accumulate causing cofactor cofactors coregulators coupling databases e2f2 elucidating erythrocyte erythroid erythropoiesis gata gata1 global globally highlight lymphocytic modulations pairs pinpoint promoters proper resource tal1 upregulate utilizing validate
Tagcloud (Difference) ?		34a arrest carcinogenic chemokine concern concerned creates ct cytotoxicity doses frequent greatly involves ionizing killer mammographies medical micro mir mirna overexposure pathways patterns presentation radiation ray scans successfully workers	accumulate causing cofactor cofactors coregulators coupling databases e2f2 elucidating erythrocyte erythroid erythropoiesis gata gata1 global globally highlight lymphocytic modulations pairs pinpoint promoters proper resource tal1 upregulate utilizing validate
Tagcloud (Intersection) ?