E2F3 and ATAD2

Number of citations of the paper that reports this interaction (PubMedID 20855524)
77

Data Source:
BioGRID (affinity chromatography technology, pull down)

		E2F3	ATAD2
Description		E2F transcription factor 3	ATPase family AAA domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Protein Import Into Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process	Nucleosome Assembly Nucleosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence G2 Phase Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Estimated glomerular filtration rate in non-diabetics ( 31451708) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Metabolite levels ( 23823483) Molybdenum levels ( 26025379) Obesity-related traits ( 23251661) Triglyceride levels ( 32203549) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006)
Interacting Genes		26 interacting genes: ATAD2 CCNA2 CCNF CDK3 DNMT3L FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RCAN1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 UCHL5 WNK1 YY1	12 interacting genes: BAG4 BCAR3 CASP8 E2F1 E2F2 E2F3 E2F4 ESR1 H3-4 H4C14 MYC NCOA3
Entrez ID		1871	29028
HPRD ID		02693	10678
Ensembl ID		ENSG00000112242	ENSG00000156802
Uniprot IDs		O00716	Q6PL18
PDB IDs			3DAI 4QSP 4QSQ 4QSR 4QSS 4QST 4QSU 4QSV 4QSW 4QSX 4QUT 4QUU 4TT2 4TT4 4TT6 4TTE 4TU4 4TU6 4TYL 4TZ2 4TZ8 5A5N 5A5O 5A5P 5A5Q 5A5R 5A81 5A82 5A83 5EPB 5F36 5F3A 5LJ0 5QXI 5QXJ 5QXK 5QXL 5QXM 5QXN 5QXO 5QXP 5QXQ 5QXR 5QXS 5QXT 5QXU 5QXV 5QXW 5QXX 5QXY 5QXZ 5QY0 5R4E 5R4F 5R4V 5R4W 5R4X 5R4Y 5R4Z 6CPS 6EPJ 6EPR 6EPS 6EPT 6EPU 6EPV 6EPW 6EPX 6HDN 6HDO 6HI3 6HI4 6HI5 6HI6 6HI7 6HI8 6HIA 6HIB 6HIC 6HID 6HIE 6S55 6S56 6S57 6YB4 7M98 7PPX 7PX5 7Q6T 7Q6U 7Q6V 7Q6W 7QU7 7QUK 7QUM 7QWO 7QX1 7QXT 7QYK 7QYL 7QZM 7QZY 7QZZ 7R00 7R05 7R0Y 7Z9H 7Z9I 7Z9J 7Z9N 7Z9O 7Z9S 7Z9U 8H3H 8JUW 8JUY 8JUZ 8RU5 8SDO 8SDQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleoplasm Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Division Chromatin Remodeling G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Organization Rb-E2F Complex Transcription Regulator Complex Cyclin-dependent Protein Kinase Holoenzyme Complex DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Mitotic Cell Cycle Phase Transition Anaphase-promoting Complex Binding Cell Cycle Phase Transition DNA Binding DNA-binding Transcription Factor Binding Positive Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance In Response To DNA Damage Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Ino80 Complex Regulation Of DNA Strand Elongation Response To Hormone Transcription Factor Binding Negative Regulation Of Calcium-mediated Signaling Regulation Of Chromosome Organization	Protein Dimerization Activity Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex DNA-binding Transcription Activator Activity RNA Polymerase II Transcription Regulator Complex Chromatin DNA-binding Transcription Factor Activity Lens Fiber Cell Apoptotic Process Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Regulation Of Fibroblast Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Developmental Process Chromatin Remodeling Apoptotic Signaling Pathway Response To Estradiol Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Nucleoplasm Nucleobase-containing Compound Biosynthetic Process Sequence-specific DNA Binding Intrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Protein-DNA Complex Assembly Cellular Response To Estradiol Stimulus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Apoptotic Process Transcription Coregulator Binding Regulation Of Myeloid Cell Differentiation Positive Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Epithelial Cell Apoptotic Process
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