PTK6 and LINC01139

Number of citations of the paper that reports this interaction (PubMedID 26751287)
62

Data Source:
BioGRID (unspecified method)

		PTK6	LINC01139
Description		protein tyrosine kinase 6	long intergenic non-protein coding RNA 1139
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding
	Biological Process	Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation ERBB2 Signaling Pathway Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization Cytoprotection by HMOX1
Drugs		Vandetanib Tivozanib Fostamatinib Zanubrutinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)
Interacting Genes		35 interacting genes: ACTN3 ANKRD55 APP AR CBLB CCDC33 DDX17 DOK1 DTX3 EFHC2 EGFR ERBB2 ERBB3 ERBB4 EXOC5 FCHO1 FGFR1 GAB1 HIF1A KHDRBS1 KHDRBS2 KIAA1217 KIT LINC01139 MEIS2 MET MKRN3 MYOZ3 PITX1 PRDM6 REL SLA STAP2 WASL ZNF341	5 interacting genes: EGFR GPNMB HIF1A LRRK2 PTK6
Entrez ID		5753	339535
HPRD ID		03594
Ensembl ID		ENSG00000101213	ENSG00000215808
Uniprot IDs		Q13882
PDB IDs		1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4 8S1C
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway SH2 Domain Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway ERBB3:ERBB2 Complex Visual Learning Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Visual Behavior Positive Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Response To Growth Factor ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Regulation Of DNA-templated Transcription Associative Learning Regulation Of RNA Biosynthetic Process Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation	Digestive Tract Morphogenesis Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Protein Modification Process ERBB2 Signaling Pathway MAP Kinase Kinase Kinase Activity Positive Regulation Of Signaling Embryonic Placenta Development Cell Migration Telencephalon Cell Migration Regulation Of Locomotion Forebrain Cell Migration Positive Regulation Of DNA Replication Negative Regulation Of Macromolecule Metabolic Process Cell Motility Regulation Of Neuroblast Proliferation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Neuron Differentiation Mitochondrion Localization Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MiRNA Transcription Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Positive Regulation Of MAPK Cascade Regulation Of ERBB Signaling Pathway Regulation Of Cellular Localization Regulation Of MiRNA Metabolic Process Protein Kinase Activity Regulation Of Protein Metabolic Process Multivesicular Body, Internal Vesicle Lumen Regulation Of Neural Precursor Cell Proliferation Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Cell Communication Positive Regulation Of Cell Migration Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Positive Regulation Of Locomotion Regulation Of Growth Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Cell Population Proliferation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
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