PTK6 and PRDM6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTK6	PRDM6
Description		protein tyrosine kinase 6	PR/SET domain 6
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Cell Projection	Nucleus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding	Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Identical Protein Binding Metal Ion Binding Histone H4K20 Monomethyltransferase Activity
	Biological Process	Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation ERBB2 Signaling Pathway Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression Neurogenesis Methylation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization Cytoprotection by HMOX1
Drugs		Vandetanib Tivozanib Fostamatinib Zanubrutinib
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Hair shape ( 29220522) Prostate cancer ( 23535732)	Body mass index ( 28892062) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618447 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072) Mammographic density (dense area) ( 25342443) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Percent mammographic density ( 25342443) Pulse pressure ( 27841878 27618447) QRS duration ( 25035420) Systolic blood pressure ( 27841878 27618447 26390057 30578418)
Interacting Genes		35 interacting genes: ACTN3 ANKRD55 APP AR CBLB CCDC33 DDX17 DOK1 DTX3 EFHC2 EGFR ERBB2 ERBB3 ERBB4 EXOC5 FCHO1 FGFR1 GAB1 HIF1A KHDRBS1 KHDRBS2 KIAA1217 KIT LINC01139 MEIS2 MET MKRN3 MYOZ3 PITX1 PRDM6 REL SLA STAP2 WASL ZNF341	71 interacting genes: ABI2 AGXT AHCYL1 AIRIM ANKS1A AQP1 ARID5A ATOSB ATPAF2 ATXN7L2 BAG3 BANF2 BANP CBFA2T2 CBX8 CCDC120 CCDC57 CCHCR1 CCNL1 CEP57L1 COX5B CSTF2 ELOA ENKD1 EXOSC5 FAM90A1 FHL2 FOXD4L1 FRS3 FTO GADD45GIP1 GEM GPANK1 GRXCR1 HOXC8 IL16 IQUB KANK2 KAT5 KCTD9 KIFC3 LMO1 LMO2 LONRF1 MYOZ3 NCK2 NEK6 NFKBID PATZ1 PIH1D2 PRKAA2 PTK6 QARS1 RAD51D ROPN1 RUNX1T1 SAMD4A SLC19A4P STK16 TCAF1 TEKT4 TLE5 TRIM14 TSGA10 TSGA10IP TSSK3 TTC23 TYW2 UBASH3A USP54 ZFYVE26
Entrez ID		5753	93166
HPRD ID		03594	19698
Ensembl ID		ENSG00000101213	ENSG00000061455
Uniprot IDs		Q13882	Q9NQX0
PDB IDs		1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4 8S1C
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway SH2 Domain Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway ERBB3:ERBB2 Complex Visual Learning Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Visual Behavior Positive Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Response To Growth Factor ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Regulation Of DNA-templated Transcription Associative Learning Regulation Of RNA Biosynthetic Process Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation	Protein Binding
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