POU2AF1 and SLC22A1

Number of citations of the paper that reports this interaction (PMID 11136971)
34

Data Source:
HPRD (in vitro)

		POU2AF1	SLC22A1
Gene Name		POU class 2 associating factor 1	solute carrier family 22 (organic cation transporter), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	DNA Binding Transcription Cofactor Activity Transcription Coactivator Activity Protein Binding	Acetylcholine Transmembrane Transporter Activity Dopamine Transmembrane Transporter Activity Norepinephrine Transmembrane Transporter Activity Protein Binding Secondary Active Organic Cation Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Humoral Immune Response	Neurotransmitter Transport Drug Transmembrane Transport Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Organic Cation Transport Quaternary Ammonium Group Transport Dopamine Transport Norepinephrine Transport Small Molecule Metabolic Process Epinephrine Transport Protein Homooligomerization Transmembrane Transport Ammonium Transmembrane Transport Acetate Ester Transport
Pathways			Na+/Cl- dependent neurotransmitter transporters Neurotransmitter Release Cycle Neurotransmitter Clearance In The Synaptic Cleft Organic cation transport Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Organic cation/anion/zwitterion transport SLC-mediated transmembrane transport Abacavir transport and metabolism Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Corneal structure ( 23291589) Primary biliary cirrhosis ( 23000144)	Metabolic traits ( 21886157) Prostate cancer ( 21743057)
Protein-Protein Interactions		16 interactors: GATA2 GTF2H1 GTF2I MSX2 NAB1 PAX8 POU2F1 POU2F2 RHOXF2 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK	2 interactors: CERS2 POU2AF1
Entrez ID		5450	6580
HPRD ID		03126	04007
Ensembl ID		ENSG00000110777	ENSG00000175003
Uniprot IDs		Q16633	O15245
PDB IDs		1CQT
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Organ Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Anatomical Structure Morphogenesis RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Differentiation Ammonium Transport Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Quaternary Ammonium Group Transport Negative Regulation Of RNA Biosynthetic Process System Development Cell Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Monoamine Transport Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Stimulus Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Drug Transmembrane Transport Signal Transduction Involved In Regulation Of Gene Expression Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Secretion By Cell Organ Development Positive Regulation Of BMP Signaling Pathway Anatomical Structure Development Ammonium Transmembrane Transport
Tagcloud ?			adopted agonists cation cml endocrine hence hoct1 imatinib improve killing leukaemia myeloid organic orphan peroxisome potentially ppar predictor pregnane proliferator pxr rank rar retinoid rxr transporter upregulated uptake wilcoxon
Tagcloud (Difference) ?			adopted agonists cation cml endocrine hence hoct1 imatinib improve killing leukaemia myeloid organic orphan peroxisome potentially ppar predictor pregnane proliferator pxr rank rar retinoid rxr transporter upregulated uptake wilcoxon
Tagcloud (Intersection) ?