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POU2AF1 and SIAH2
Number of citations of the paper that reports this interaction (PMID
11483518
)
21
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
POU2AF1
SIAH2
Gene Name
POU class 2 associating factor 1
siah E3 ubiquitin protein ligase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Neuron Projection
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Molecular Function
DNA Binding
Transcription Cofactor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Corepressor Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Conjugating Enzyme Binding
Biological Process
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Humoral Immune Response
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Small GTPase Mediated Signal Transduction
Axon Guidance
Protein Ubiquitination
Regulation Of Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Catabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Axon guidance
Netrin-1 signaling
Drugs
Diseases
GWAS
Corneal structure (
23291589
)
Primary biliary cirrhosis (
23000144
)
Breast cancer (
22951594
)
Protein-Protein Interactions
16 interactors:
GATA2
GTF2H1
GTF2I
MSX2
NAB1
PAX8
POU2F1
POU2F2
RHOXF2
SIAH1
SIAH2
SLC22A1
SLC22A2
SMAD2
SUB1
SYK
39 interactors:
AFF1
ATN1
CACYBP
CCBE1
DCC
DYRK2
EEF1D
EGLN3
HIPK2
HIPK3
MYD88
OPRM1
PEG10
PEG3
PIAS1
PIAS2
PIAS3
PML
POU2AF1
PSMD4
RBBP8
SETD2
SNCA
SNCAIP
SPRY2
STAT3
SYP
TINF2
TP53BP2
TPX2
TRAF2
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2L6
USP13
USP19
VAV1
Entrez ID
5450
6478
HPRD ID
03126
03737
Ensembl ID
ENSG00000110777
ENSG00000181788
Uniprot IDs
Q16633
O43255
PDB IDs
1CQT
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Transcription, DNA-templated
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Organ Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Biosynthetic Process
Regulation Of Metabolic Process
Anatomical Structure Morphogenesis
RNA Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Cell Differentiation
Ammonium Transport
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Embryonic Morphogenesis
Negative Regulation Of Nucleic Acid-templated Transcription
Quaternary Ammonium Group Transport
Negative Regulation Of RNA Biosynthetic Process
System Development
Cell Development
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Monoamine Transport
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Response To Stimulus
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Drug Transmembrane Transport
Signal Transduction Involved In Regulation Of Gene Expression
Multicellular Organismal Development
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Metabolic Process
Secretion By Cell
Organ Development
Positive Regulation Of BMP Signaling Pathway
Anatomical Structure Development
Ammonium Transmembrane Transport
Regulation Of Nitrogen Compound Metabolic Process
Apoptotic Process
Regulation Of Metabolic Process
Programmed Cell Death
Cell Death
Regulation Of Cellular Process
Death
Positive Regulation Of Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of Transcription, DNA-templated
Cellular Response To Stress
Regulation Of Protein Metabolic Process
Response To Growth Factor
Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Modification-dependent Protein Catabolic Process
Protein Sumoylation
Response To Organic Substance
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Cellular Protein Metabolic Process
Proteasomal Protein Catabolic Process
Cellular Protein Catabolic Process
Toll-like Receptor 4 Signaling Pathway
Cellular Response To Growth Factor Stimulus
Response To Stress
Negative Regulation Of Cellular Metabolic Process
Cellular Response To Stimulus
Innate Immune Response
Positive Regulation Of Proteolysis
Regulation Of Cell Death
Immune Response
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Cellular Response To Organic Substance
Cellular Protein Modification Process
Cellular Macromolecule Catabolic Process
Defense Response
Negative Regulation Of Biosynthetic Process
Regulation Of Proteolysis
Toll-like Receptor Signaling Pathway
Tagcloud
?
adding
complexity
decisions
determines
e3
fail
fate
favoring
feedback
finger
hipk2
homeodomain
inactivated
interferes
ligase
loop
preferentially
proline
stimulates
switch
termination
ubiquitin
ubiquitination
uncovers
waf1
xaf1
xiap
zinc
znf313
Tagcloud (Difference)
?
adding
complexity
decisions
determines
e3
fail
fate
favoring
feedback
finger
hipk2
homeodomain
inactivated
interferes
ligase
loop
preferentially
proline
stimulates
switch
termination
ubiquitin
ubiquitination
uncovers
waf1
xaf1
xiap
zinc
znf313
Tagcloud (Intersection)
?